Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation
Solid pseudopapillary neoplasms (SPNs) primarily arise in the pancreas and are uncommon in the ovaries. Here, we present a case of ovarian-origin SPN. Alongside the typical solid and pseudopapillary structures, “cholesteroma-like” denaturation areas and tissue degeneration regions are also observed....
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514460/full |
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| author | Ziqing Zhao Jiahui Lin Tingting Bai Hongfeng Liao Zhengjin Liu |
| author_facet | Ziqing Zhao Jiahui Lin Tingting Bai Hongfeng Liao Zhengjin Liu |
| author_sort | Ziqing Zhao |
| collection | DOAJ |
| description | Solid pseudopapillary neoplasms (SPNs) primarily arise in the pancreas and are uncommon in the ovaries. Here, we present a case of ovarian-origin SPN. Alongside the typical solid and pseudopapillary structures, “cholesteroma-like” denaturation areas and tissue degeneration regions are also observed. Immunohistochemistry analysis demonstrates positive results for β-catenin (nucleus), CD99 (dot-like), CD56, and vimentin. Imaging studies rule out pancreatic or other origins. This study aims to enhance comprehension, diagnosis, and differential diagnosis of primary ovarian SPN among pathologists and clinicians, as well as to investigate the origin and management of primary solid pseudopapillary tumors in the ovary. |
| format | Article |
| id | doaj-art-5aee2f6e9c684c1a975e978aa7c5f3f2 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5aee2f6e9c684c1a975e978aa7c5f3f22025-08-20T03:01:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15144601514460Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturationZiqing Zhao0Jiahui Lin1Tingting Bai2Hongfeng Liao3Zhengjin Liu4Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaSolid pseudopapillary neoplasms (SPNs) primarily arise in the pancreas and are uncommon in the ovaries. Here, we present a case of ovarian-origin SPN. Alongside the typical solid and pseudopapillary structures, “cholesteroma-like” denaturation areas and tissue degeneration regions are also observed. Immunohistochemistry analysis demonstrates positive results for β-catenin (nucleus), CD99 (dot-like), CD56, and vimentin. Imaging studies rule out pancreatic or other origins. This study aims to enhance comprehension, diagnosis, and differential diagnosis of primary ovarian SPN among pathologists and clinicians, as well as to investigate the origin and management of primary solid pseudopapillary tumors in the ovary.https://www.frontiersin.org/articles/10.3389/fonc.2025.1514460/fullsolid pseudopapillary neoplasmovaryβ-cateninprimarily“cholesteroma-like” denaturation |
| spellingShingle | Ziqing Zhao Jiahui Lin Tingting Bai Hongfeng Liao Zhengjin Liu Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation Frontiers in Oncology solid pseudopapillary neoplasm ovary β-catenin primarily “cholesteroma-like” denaturation |
| title | Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation |
| title_full | Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation |
| title_fullStr | Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation |
| title_full_unstemmed | Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation |
| title_short | Case Report: Primary solid pseudopapillary neoplasm of the ovary with “cholesteroma-like” denaturation |
| title_sort | case report primary solid pseudopapillary neoplasm of the ovary with cholesteroma like denaturation |
| topic | solid pseudopapillary neoplasm ovary β-catenin primarily “cholesteroma-like” denaturation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514460/full |
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