Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release
Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the ra...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2014/169210 |
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| _version_ | 1849434942185930752 |
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| author | Ranran Zhang Risheng Yao Binbin Ding Yuxin Shen Shengwen Shui Lei Wang Yu Li Xianzhu Yang Wei Tao |
| author_facet | Ranran Zhang Risheng Yao Binbin Ding Yuxin Shen Shengwen Shui Lei Wang Yu Li Xianzhu Yang Wei Tao |
| author_sort | Ranran Zhang |
| collection | DOAJ |
| description | Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on
normal tissue limit exploiting nanocarriers for the application of light-controlled drug
release. Two strategies may solve the problem: one is to improve the sensitivity of the
nanocarriers to light to decrease the radiation time; the other one is using more
friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle
with an upconverting nanoparticle (UCNP) as the core and thermo- and
light-responsive block copolymers as the shell to combine the two strategies together.
The results indicated that the sensitivity of the block copolymer to light could be enhanced
by decreasing the photolabile moieties in the polymer, and the UCNP could transfer
near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to
trigger the phase conversion of the block polymers in situ. Using Nile Red (NR) as the
model drug, the hybrid nanoparticles were further proved to be able to act as carriers
with the character of NIR triggered drug release. |
| format | Article |
| id | doaj-art-5ad54c690f404fa897f23cfd2949d7f4 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-5ad54c690f404fa897f23cfd2949d7f42025-08-20T03:26:29ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422014-01-01201410.1155/2014/169210169210Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug ReleaseRanran Zhang0Risheng Yao1Binbin Ding2Yuxin Shen3Shengwen Shui4Lei Wang5Yu Li6Xianzhu Yang7Wei Tao8School of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Material Science and Engineering, Wuhan University of Technology, Wuhan, Hubei, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaSchool of Medical Engineering, Hefei University of Engineering, Hefei, Anhui, ChinaLow tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymers in situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.http://dx.doi.org/10.1155/2014/169210 |
| spellingShingle | Ranran Zhang Risheng Yao Binbin Ding Yuxin Shen Shengwen Shui Lei Wang Yu Li Xianzhu Yang Wei Tao Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release Advances in Materials Science and Engineering |
| title | Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release |
| title_full | Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release |
| title_fullStr | Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release |
| title_full_unstemmed | Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release |
| title_short | Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release |
| title_sort | fabrication of upconverting hybrid nanoparticles for near infrared light triggered drug release |
| url | http://dx.doi.org/10.1155/2014/169210 |
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