Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4

Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4

Abstract Purpose Among malignant tumors, non-small cell lung cancer (NSCLC) remains a major threat to human life and health. Studies have illustrated that minichromosome maintenance protein 4 (MCM4) has complex interactions with the progression of many cancers, yet the role and mechanism of MCM4 in...

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Bibliographic Details
Main Authors: Yuyin Cai, Xinyan Lu, Tingting Li, Jia Liu, Lifeng Jiang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Cardiothoracic Surgery
Subjects:
NSCLC
MCM4
E2F1
Progression
Xenograft model
Online Access:https://doi.org/10.1186/s13019-025-03481-z
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