COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China
<b>Objectives</b>: Accumulating evidence has confirmed the efficacy and safety of COVID-19 vaccines against SARS-CoV-2 infection. However, the effect of COVID-19 vaccination on immuno-virological parameters in people with HIV (PWH) is uncertain. <b>Methods</b>: A total of 372...
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2024-12-01
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| author | Yanyan Li Yingying Lin Yunyun Yi Na Zhu Xinyu Cui Xin Li |
| author_facet | Yanyan Li Yingying Lin Yunyun Yi Na Zhu Xinyu Cui Xin Li |
| author_sort | Yanyan Li |
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| description | <b>Objectives</b>: Accumulating evidence has confirmed the efficacy and safety of COVID-19 vaccines against SARS-CoV-2 infection. However, the effect of COVID-19 vaccination on immuno-virological parameters in people with HIV (PWH) is uncertain. <b>Methods</b>: A total of 372 PWH treated at Beijing Ditan Hospital were included. Unvaccinated PWH were matched 1:3 with vaccinated PWH using a propensity score matching algorithm. Differences in immuno-virological markers between the matched groups were analyzed. The Wilcoxon signed rank test was used to test for changes in CD4 and CD8 counts and HIV viral load over two months around vaccination. In addition, we investigated the long-term changes in HIV-related markers in different vaccination dose groups and in the entire vaccinated population. <b>Results</b>: Vaccinated PWH had a higher CD4/CD8 ratio (0.64 (0.49, 0.78) vs. 0.80 (0.56, 1.03), <i>p</i> = 0.037) than unvaccinated PWH within a two-month window after the third dose. There were 337 PWH who received COVID-19 vaccination, and 73.9% (n = 249) received three doses of vaccine. We observed a transient increase in CD4 count and CD4/CD8 ratio within a two-month window after vaccination, especially after the second dose (CD4 count: 583.5 (428.5, 706.8) vs. 618.0 (452.0, 744.0), <i>p</i> = 0.018; CD4/CD8 ratio: 0.70 (0.50, 0.91) vs. 0.71 (0.53, 0.96), <i>p</i> < 0.001)) and the third dose (CD4 count: 575.5 (435.5, 717.0) vs. 577.5 (440.8, 754.8), <i>p</i> = 0.001; CD4/CD8 ratio: 0.70 (0.52, 0.93) vs. 0.79 (0.53, 1.00), <i>p</i> < 0.001)). Recent CD4 counts and CD4/CD8 ratios were lower than after COVID-19 but remained higher than before COVID-19 in vaccinated PWH. In addition, COVID-19 vaccination had no negative effect on HIV viral load. <b>Conclusions</b>: A transient increase in CD4 count and CD4/CD8 ratio was observed after COVID-19 vaccination. However, the enhanced cellular immune response induced by vaccination may diminish over time and return to normal levels. There is no adverse effect of vaccination on HIV viral load. |
| format | Article |
| id | doaj-art-5ad252a10f3c4058960f337b7e86bcff |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-5ad252a10f3c4058960f337b7e86bcff2024-12-27T14:58:00ZengMDPI AGVaccines2076-393X2024-12-011212136510.3390/vaccines12121365COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from ChinaYanyan Li0Yingying Lin1Yunyun Yi2Na Zhu3Xinyu Cui4Xin Li5Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaCenter of Integrative Medicine, Peking University Ditan Teaching Hospital, Beijing 100015, ChinaTuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The Eighth Medical Center of PLA General Hospital, PLA General Hospital, Beijing 100853, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China<b>Objectives</b>: Accumulating evidence has confirmed the efficacy and safety of COVID-19 vaccines against SARS-CoV-2 infection. However, the effect of COVID-19 vaccination on immuno-virological parameters in people with HIV (PWH) is uncertain. <b>Methods</b>: A total of 372 PWH treated at Beijing Ditan Hospital were included. Unvaccinated PWH were matched 1:3 with vaccinated PWH using a propensity score matching algorithm. Differences in immuno-virological markers between the matched groups were analyzed. The Wilcoxon signed rank test was used to test for changes in CD4 and CD8 counts and HIV viral load over two months around vaccination. In addition, we investigated the long-term changes in HIV-related markers in different vaccination dose groups and in the entire vaccinated population. <b>Results</b>: Vaccinated PWH had a higher CD4/CD8 ratio (0.64 (0.49, 0.78) vs. 0.80 (0.56, 1.03), <i>p</i> = 0.037) than unvaccinated PWH within a two-month window after the third dose. There were 337 PWH who received COVID-19 vaccination, and 73.9% (n = 249) received three doses of vaccine. We observed a transient increase in CD4 count and CD4/CD8 ratio within a two-month window after vaccination, especially after the second dose (CD4 count: 583.5 (428.5, 706.8) vs. 618.0 (452.0, 744.0), <i>p</i> = 0.018; CD4/CD8 ratio: 0.70 (0.50, 0.91) vs. 0.71 (0.53, 0.96), <i>p</i> < 0.001)) and the third dose (CD4 count: 575.5 (435.5, 717.0) vs. 577.5 (440.8, 754.8), <i>p</i> = 0.001; CD4/CD8 ratio: 0.70 (0.52, 0.93) vs. 0.79 (0.53, 1.00), <i>p</i> < 0.001)). Recent CD4 counts and CD4/CD8 ratios were lower than after COVID-19 but remained higher than before COVID-19 in vaccinated PWH. In addition, COVID-19 vaccination had no negative effect on HIV viral load. <b>Conclusions</b>: A transient increase in CD4 count and CD4/CD8 ratio was observed after COVID-19 vaccination. However, the enhanced cellular immune response induced by vaccination may diminish over time and return to normal levels. There is no adverse effect of vaccination on HIV viral load.https://www.mdpi.com/2076-393X/12/12/1365HIVCOVID-19 vaccineCD4 countCD4/CD8 ratioimmune response |
| spellingShingle | Yanyan Li Yingying Lin Yunyun Yi Na Zhu Xinyu Cui Xin Li COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China Vaccines HIV COVID-19 vaccine CD4 count CD4/CD8 ratio immune response |
| title | COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China |
| title_full | COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China |
| title_fullStr | COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China |
| title_full_unstemmed | COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China |
| title_short | COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China |
| title_sort | covid 19 vaccination and transient increase in cd4 cd8 cell counts in people with hiv evidence from china |
| topic | HIV COVID-19 vaccine CD4 count CD4/CD8 ratio immune response |
| url | https://www.mdpi.com/2076-393X/12/12/1365 |
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