Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization
Hematopoietic stem cell transplant (HSCT) using mobilized peripheral blood hematopoietic stem cells (HSPCs) is the only curative strategy for many patients suffering from hematological malignancies. HSPC collection protocols rely on pharmacological agents to mobilize HSPCs to peripheral blood. Limit...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7131359 |
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| author | Russell Emmons Grace M. Niemiro Michael De Lisio |
| author_facet | Russell Emmons Grace M. Niemiro Michael De Lisio |
| author_sort | Russell Emmons |
| collection | DOAJ |
| description | Hematopoietic stem cell transplant (HSCT) using mobilized peripheral blood hematopoietic stem cells (HSPCs) is the only curative strategy for many patients suffering from hematological malignancies. HSPC collection protocols rely on pharmacological agents to mobilize HSPCs to peripheral blood. Limitations including variable donor responses and long dosing protocols merit further investigations into adjuvant therapies to enhance the efficiency of HSPCs collection. Exercise, a safe and feasible intervention in patients undergoing HSCT, has been previously shown to robustly stimulate HSPC mobilization from the bone marrow. Exercise-induced HSPC mobilization is transient limiting its current clinical potential. Thus, a deeper investigation of the mechanisms responsible for exercise-induced HSPC mobilization and the factors responsible for removal of HSPCs from circulation following exercise is warranted. The present review will describe current research on exercise and HSPC mobilization, outline the potential mechanisms responsible for exercise-induced HSPC mobilization, and highlight potential sites for HSPC homing following exercise. We also outline current barriers to the implementation of exercise as an adjuvant therapy for HSPC mobilization and suggest potential strategies to overcome these barriers. |
| format | Article |
| id | doaj-art-5ad2161acdb34cb5b0a22e40a3c4fe6e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5ad2161acdb34cb5b0a22e40a3c4fe6e2025-02-03T01:23:40ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/71313597131359Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell MobilizationRussell Emmons0Grace M. Niemiro1Michael De Lisio2Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAHematopoietic stem cell transplant (HSCT) using mobilized peripheral blood hematopoietic stem cells (HSPCs) is the only curative strategy for many patients suffering from hematological malignancies. HSPC collection protocols rely on pharmacological agents to mobilize HSPCs to peripheral blood. Limitations including variable donor responses and long dosing protocols merit further investigations into adjuvant therapies to enhance the efficiency of HSPCs collection. Exercise, a safe and feasible intervention in patients undergoing HSCT, has been previously shown to robustly stimulate HSPC mobilization from the bone marrow. Exercise-induced HSPC mobilization is transient limiting its current clinical potential. Thus, a deeper investigation of the mechanisms responsible for exercise-induced HSPC mobilization and the factors responsible for removal of HSPCs from circulation following exercise is warranted. The present review will describe current research on exercise and HSPC mobilization, outline the potential mechanisms responsible for exercise-induced HSPC mobilization, and highlight potential sites for HSPC homing following exercise. We also outline current barriers to the implementation of exercise as an adjuvant therapy for HSPC mobilization and suggest potential strategies to overcome these barriers.http://dx.doi.org/10.1155/2016/7131359 |
| spellingShingle | Russell Emmons Grace M. Niemiro Michael De Lisio Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization Stem Cells International |
| title | Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization |
| title_full | Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization |
| title_fullStr | Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization |
| title_full_unstemmed | Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization |
| title_short | Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization |
| title_sort | exercise as an adjuvant therapy for hematopoietic stem cell mobilization |
| url | http://dx.doi.org/10.1155/2016/7131359 |
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