Neuroprotective Effects of Bacterial Melanin in a Rotenone-Induced Parkinson’s Disease Rat Model: Electrophysiological Evidence from Cortical Stimulation of Substantia Nigra Neurons

Neuroprotective Effects of Bacterial Melanin in a Rotenone-Induced Parkinson’s Disease Rat Model: Electrophysiological Evidence from Cortical Stimulation of Substantia Nigra Neurons

<b>Background/Objectives:</b> As the regulatory center for basal ganglia, the substantia nigra is involved in the pathophysiology of dopaminergic dysregulation in Parkinson’s disease (PD). Increasing neuronal excitability of dopaminergic neurons by different therapeutic methods could rev...

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Bibliographic Details
Main Authors: John Sarkissian, Michael Poghosyan, Margarita Danielyan, Narek Makaryan, Tigran Petrosyan, Sona Avetisyan, Anichka Hovsepyan
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
Parkinson’s disease model
substantia nigra
rotenone infusion
melanin
electrical activity
cortico-nigral stimulation
Online Access:https://www.mdpi.com/2227-9059/13/6/1317
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