Treatment of agitation in dementia - a systematic review
Abstract Dementia, including Alzheimer’s disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic review evaluates pharmacological and non-p...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | International Journal of Emergency Medicine |
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| Online Access: | https://doi.org/10.1186/s12245-025-00902-7 |
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| _version_ | 1850105554797592576 |
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| author | Misha Choudry Murdoc Gould Latha Ganti |
| author_facet | Misha Choudry Murdoc Gould Latha Ganti |
| author_sort | Misha Choudry |
| collection | DOAJ |
| description | Abstract Dementia, including Alzheimer’s disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic review evaluates pharmacological and non-pharmacological interventions for managing agitation in dementia. Nine clinical studies were analyzed, encompassing medications like brexpiprazole and non-pharmacological approaches such as music therapy and digital care programs. Pharmacological treatments showed mixed efficacy and safety profiles, with brexpiprazole demonstrating dose-dependent benefits and mirtazapine associating with higher mortality rates. Non-pharmacological interventions exhibited promising results in reducing agitation without adverse effects. The review underscores the importance of personalized care strategies tailored to individual patient needs and preferences to enhance treatment efficacy and quality of life, highlighting the shift toward holistic, individualized care. |
| format | Article |
| id | doaj-art-5ac6163de9d9473bbd306ee9223a4ffe |
| institution | OA Journals |
| issn | 1865-1380 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Emergency Medicine |
| spelling | doaj-art-5ac6163de9d9473bbd306ee9223a4ffe2025-08-20T02:39:03ZengBMCInternational Journal of Emergency Medicine1865-13802025-05-011811710.1186/s12245-025-00902-7Treatment of agitation in dementia - a systematic reviewMisha Choudry0Murdoc Gould1Latha Ganti2Trinity Preparatory SchoolBirkbeck, University of LondonOrlando College of Osteopathic MedicineAbstract Dementia, including Alzheimer’s disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic review evaluates pharmacological and non-pharmacological interventions for managing agitation in dementia. Nine clinical studies were analyzed, encompassing medications like brexpiprazole and non-pharmacological approaches such as music therapy and digital care programs. Pharmacological treatments showed mixed efficacy and safety profiles, with brexpiprazole demonstrating dose-dependent benefits and mirtazapine associating with higher mortality rates. Non-pharmacological interventions exhibited promising results in reducing agitation without adverse effects. The review underscores the importance of personalized care strategies tailored to individual patient needs and preferences to enhance treatment efficacy and quality of life, highlighting the shift toward holistic, individualized care.https://doi.org/10.1186/s12245-025-00902-7DementiaSystematic reviewAgitation |
| spellingShingle | Misha Choudry Murdoc Gould Latha Ganti Treatment of agitation in dementia - a systematic review International Journal of Emergency Medicine Dementia Systematic review Agitation |
| title | Treatment of agitation in dementia - a systematic review |
| title_full | Treatment of agitation in dementia - a systematic review |
| title_fullStr | Treatment of agitation in dementia - a systematic review |
| title_full_unstemmed | Treatment of agitation in dementia - a systematic review |
| title_short | Treatment of agitation in dementia - a systematic review |
| title_sort | treatment of agitation in dementia a systematic review |
| topic | Dementia Systematic review Agitation |
| url | https://doi.org/10.1186/s12245-025-00902-7 |
| work_keys_str_mv | AT mishachoudry treatmentofagitationindementiaasystematicreview AT murdocgould treatmentofagitationindementiaasystematicreview AT lathaganti treatmentofagitationindementiaasystematicreview |