Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis
Introduction The thyroid cancer incidence has been increasing all over the world. However, the aetiology of thyroid cancer remains unclear. A growing body of evidence suggested exposure to persistent organic pollutants (POPs) may play a role in the initiation of thyroid cancer, but the results are g...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e048451.full |
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| author | Yu Xue Zhang Yu Peng Liu Su Sheng Miao Xiao Dong Liu Shu Mei Ma Zhang Yi Qu |
| author_facet | Yu Xue Zhang Yu Peng Liu Su Sheng Miao Xiao Dong Liu Shu Mei Ma Zhang Yi Qu |
| author_sort | Yu Xue Zhang |
| collection | DOAJ |
| description | Introduction The thyroid cancer incidence has been increasing all over the world. However, the aetiology of thyroid cancer remains unclear. A growing body of evidence suggested exposure to persistent organic pollutants (POPs) may play a role in the initiation of thyroid cancer, but the results are generally inconsistent across studies. This review aims to synthesise the evidence for the health effects of POPs on the risk of thyroid cancer.Methods and analysis This protocol was reported in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA) statements. A comprehensive search, including electronic database search (eg, PubMed, Embase, ProQuest and CNKI), website search and manual search, will be performed to identify all eligible studies. The Population, Exposure, Comparator and Outcome framework was used to clarify the inclusion and exclusion criteria. The Newcastle-Ottawa Scale will be used to assess the quality of included studies. Maximally adjusted effect estimates from individual studies will be summarised with random-effect models in a conservative manner. I2 statistics and Q-tests will be used to test the heterogeneity across studies. We will perform extensive sensitivity analyses, such as confounding risk ratio (confounding), E-value, fixed-effect models, excluding the most relatively weighted study, including only the high-quality studies and many predesigned subgroup analyses, etc. The findings will be reported in accordance to the PRISMA guidelines.Ethics and dissemination Ethical approval is not required in this systematic review of published literatures. The results will be published in a peer-reviewed journal and presented at relevant conferences.PROSPERO registration number CRD42020181343. |
| format | Article |
| id | doaj-art-5abe57bc31414910a2407dda8ce25eb8 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-5abe57bc31414910a2407dda8ce25eb82025-08-20T02:20:38ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-048451Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysisYu Xue Zhang0Yu Peng Liu1Su Sheng Miao2Xiao Dong Liu3Shu Mei Ma4Zhang Yi Qu5Department of Preventive Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Occupational and Environmental Health, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Occupational and Environmental Health, School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaDepartment of Hygiene Microbiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, ChinaIntroduction The thyroid cancer incidence has been increasing all over the world. However, the aetiology of thyroid cancer remains unclear. A growing body of evidence suggested exposure to persistent organic pollutants (POPs) may play a role in the initiation of thyroid cancer, but the results are generally inconsistent across studies. This review aims to synthesise the evidence for the health effects of POPs on the risk of thyroid cancer.Methods and analysis This protocol was reported in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA) statements. A comprehensive search, including electronic database search (eg, PubMed, Embase, ProQuest and CNKI), website search and manual search, will be performed to identify all eligible studies. The Population, Exposure, Comparator and Outcome framework was used to clarify the inclusion and exclusion criteria. The Newcastle-Ottawa Scale will be used to assess the quality of included studies. Maximally adjusted effect estimates from individual studies will be summarised with random-effect models in a conservative manner. I2 statistics and Q-tests will be used to test the heterogeneity across studies. We will perform extensive sensitivity analyses, such as confounding risk ratio (confounding), E-value, fixed-effect models, excluding the most relatively weighted study, including only the high-quality studies and many predesigned subgroup analyses, etc. The findings will be reported in accordance to the PRISMA guidelines.Ethics and dissemination Ethical approval is not required in this systematic review of published literatures. The results will be published in a peer-reviewed journal and presented at relevant conferences.PROSPERO registration number CRD42020181343.https://bmjopen.bmj.com/content/11/8/e048451.full |
| spellingShingle | Yu Xue Zhang Yu Peng Liu Su Sheng Miao Xiao Dong Liu Shu Mei Ma Zhang Yi Qu Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis BMJ Open |
| title | Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis |
| title_full | Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis |
| title_fullStr | Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis |
| title_full_unstemmed | Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis |
| title_short | Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis |
| title_sort | exposure to persistent organic pollutants and thyroid cancer risk a study protocol of systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/11/8/e048451.full |
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