Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.

Malaria poses an enormous threat to human health. With ever-increasing resistance to currently deployed antimalarials, new targets and starting point compounds with novel mechanisms of action need to be identified. Here, we explore the antimalarial activity of the Streptomyces sp natural product, 5&...

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Main Authors: Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, Yogavel Manickam, Yogesh Khandokar, Xi Ye, Con Dogovski, David H Hilko, Craig J Morton, Anne-Sophie C Braun, Michael G Leeming, Bagale Siddharam, Gerald J Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, Sally-Ann Poulsen, Michael D W Griffin, Amit Sharma, Leann Tilley, Stanley C Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013057
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