CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE?
Aim. The purpose of this study was to access clinical application of the 9p21.3 locusgenotype in patients with myocardial infarction (MI).Material and methods. Totally 500 (411 male, 89 female) patients with MI youngerthan 65 years old [Ме 54,0; Q25 48,0; Q 59,0] and 31 autopsy data (24 male,7 femal...
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«FIRMA «SILICEA» LLC
2014-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/27 |
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| author | P. A. Shesternya S. Yu. Nikulina V. A. Shulman A. S. Sergeeva A. I. Demkina V. N. Maksimov М. I. Voevoda |
| author_facet | P. A. Shesternya S. Yu. Nikulina V. A. Shulman A. S. Sergeeva A. I. Demkina V. N. Maksimov М. I. Voevoda |
| author_sort | P. A. Shesternya |
| collection | DOAJ |
| description | Aim. The purpose of this study was to access clinical application of the 9p21.3 locusgenotype in patients with myocardial infarction (MI).Material and methods. Totally 500 (411 male, 89 female) patients with MI youngerthan 65 years old [Ме 54,0; Q25 48,0; Q 59,0] and 31 autopsy data (24 male,7 female) in case of fatal MI were collected. All participants were included in the 75study after written informed consent form. Control group consisted of 535 participants (423 male, 112 female) without coronary artery disease [Ме 42,6;Q25 39,0; Q 44,3]. Genome DNA was extracted from venous blood or myocardialtissue using the phenol-chloroform extraction method. Two SNPs rs10757278 andrs1333049 (locus 9p21.3) were tested. Prospective follow-up period lasted 2 years.Results. We revealed a direct strong association of the locus 9р21.3 (rs1333049)with MI. Logistic regression odds ratio (OR) of MI for homozygous genotype CCrs1333049 was 1,71 [95% CI: 1,16-2,52], р=0,006. In patient who didn’t underwent PCI and carried of risk allele C rs1333049 had significant higher risk of recurrent 75acute coronary syndrome (ACS): during 1 year after MI – OR=4,91 [95% CI: 1,4516,66];during2yearafterMI–OR=3,77[95%CI:1,50-9,52].Conclusion.We suppose these data might be effectively utilized for improvement of onset of MI and long-term outcome prognosis. |
| format | Article |
| id | doaj-art-5aba3480e096414788ec785535d18edd |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-5aba3480e096414788ec785535d18edd2025-08-20T03:57:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-10-0101071210.15829/1560-4071-2014-10-7-1227CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE?P. A. Shesternya0S. Yu. Nikulina1V. A. Shulman2A. S. Sergeeva3A. I. Demkina4V. N. Maksimov5М. I. Voevoda6Krasnoyarsk State Medical University n. a. prof. Voino-YasenetskyKrasnoyarsk State Medical University n. a. prof. Voino-YasenetskyKrasnoyarsk State Medical University n. a. prof. Voino-YasenetskyKrasnoyarsk State Medical University n. a. prof. Voino-YasenetskyKrasnoyarsk State Medical University n. a. prof. Voino-YasenetskyScientific Research Institute for Therapy and Preventive Medicine of the SB RAMS, NovosibirskScientific Research Institute for Therapy and Preventive Medicine of the SB RAMS, NovosibirskAim. The purpose of this study was to access clinical application of the 9p21.3 locusgenotype in patients with myocardial infarction (MI).Material and methods. Totally 500 (411 male, 89 female) patients with MI youngerthan 65 years old [Ме 54,0; Q25 48,0; Q 59,0] and 31 autopsy data (24 male,7 female) in case of fatal MI were collected. All participants were included in the 75study after written informed consent form. Control group consisted of 535 participants (423 male, 112 female) without coronary artery disease [Ме 42,6;Q25 39,0; Q 44,3]. Genome DNA was extracted from venous blood or myocardialtissue using the phenol-chloroform extraction method. Two SNPs rs10757278 andrs1333049 (locus 9p21.3) were tested. Prospective follow-up period lasted 2 years.Results. We revealed a direct strong association of the locus 9р21.3 (rs1333049)with MI. Logistic regression odds ratio (OR) of MI for homozygous genotype CCrs1333049 was 1,71 [95% CI: 1,16-2,52], р=0,006. In patient who didn’t underwent PCI and carried of risk allele C rs1333049 had significant higher risk of recurrent 75acute coronary syndrome (ACS): during 1 year after MI – OR=4,91 [95% CI: 1,4516,66];during2yearafterMI–OR=3,77[95%CI:1,50-9,52].Conclusion.We suppose these data might be effectively utilized for improvement of onset of MI and long-term outcome prognosis.https://russjcardiol.elpub.ru/jour/article/view/27myocardial infarctionsingle nucleotide polymorphismrs10757278rs1333049locus 9p21.3outcome |
| spellingShingle | P. A. Shesternya S. Yu. Nikulina V. A. Shulman A. S. Sergeeva A. I. Demkina V. N. Maksimov М. I. Voevoda CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? Российский кардиологический журнал myocardial infarction single nucleotide polymorphism rs10757278 rs1333049 locus 9p21.3 outcome |
| title | CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? |
| title_full | CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? |
| title_fullStr | CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? |
| title_full_unstemmed | CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? |
| title_short | CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR FUTURE? |
| title_sort | clinical significance of coronary artery disease genetic markers reality or far future |
| topic | myocardial infarction single nucleotide polymorphism rs10757278 rs1333049 locus 9p21.3 outcome |
| url | https://russjcardiol.elpub.ru/jour/article/view/27 |
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