Predictors of failure to transition from pediatric to adult nephrology care
Abstract Background The increased prevalence and life expectancy of young adults with chronic kidney disease has led to a greater need to transition patients from pediatric to adult nephrology care. This care transition occurs at a highly vulnerable time in life, and rates of unsuccessful transition...
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BMC
2025-07-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-04225-w |
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| author | Laura Nishi Jay Kang Cybele Ghossein |
| author_facet | Laura Nishi Jay Kang Cybele Ghossein |
| author_sort | Laura Nishi |
| collection | DOAJ |
| description | Abstract Background The increased prevalence and life expectancy of young adults with chronic kidney disease has led to a greater need to transition patients from pediatric to adult nephrology care. This care transition occurs at a highly vulnerable time in life, and rates of unsuccessful transition are high. Evidence-based transition protocols can greatly facilitate the process. Accordingly, Northwestern Medicine (NM) partnered with Lurie Children’s Hospital (LCH) in 2014 to develop a nephrology transition clinic to help support these high-risk patients. To best allocate resources, it is important to identify those young adults most vulnerable to drop out. Here we report on the success of our clinic and factors affecting failure to transition. Methods This was a retrospective chart review of patients seen in the NM/LCH transition clinic from 2014 to 2022. Demographic and clinical data of diagnosis, zip code, distance from clinic, average household income, parental/caregiver presence, working/school status, no-show rate, insurance, and baseline kidney function were collected. For those who successfully transitioned, data on prompt communications were also collected. Results Overall, 92% of patients successfully transitioned to adult care. 27% of patients missed their first adult center appointment and required execution of a prompt protocol. After this intervention, an additional 19% of patients successfully transitioned. 39% of those who failed to transition had a primary diagnosis of hypertension as compared to only 9% in those who transitioned successfully. Those who successfully transitioned had a lower mean estimated glomerular filtration rate of 89 mL/min/1.73 m² as compared to 116 mL/min/1.73 m² in the group who failed to transition. 15% of those who failed to transition lacked insurance as compared to only 1% of patients who successfully transitioned. Finally, those who required prompts had a significantly higher no-show rate at the pediatric center at 10% as compared to 6% in those not requiring prompts. Conclusion Transition clinics can help promote the successful transition from pediatric to adult nephrology care. Higher kidney function, lack of insurance, and primary diagnosis of hypertension were significantly correlated with failure to transition, and a higher pediatric center no-show rate was significantly correlated with the need for prompts in this single-center study. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-5ab8ccd388dd4eb5b1e13df349ce0cd3 |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-5ab8ccd388dd4eb5b1e13df349ce0cd32025-08-20T04:01:53ZengBMCBMC Nephrology1471-23692025-07-012611710.1186/s12882-025-04225-wPredictors of failure to transition from pediatric to adult nephrology careLaura Nishi0Jay Kang1Cybele Ghossein2Division of Nephrology, Northwestern University Feinberg School of MedicineUniversity of Pennsylvania Perelman School of MedicineDivision of Nephrology, Northwestern University Feinberg School of MedicineAbstract Background The increased prevalence and life expectancy of young adults with chronic kidney disease has led to a greater need to transition patients from pediatric to adult nephrology care. This care transition occurs at a highly vulnerable time in life, and rates of unsuccessful transition are high. Evidence-based transition protocols can greatly facilitate the process. Accordingly, Northwestern Medicine (NM) partnered with Lurie Children’s Hospital (LCH) in 2014 to develop a nephrology transition clinic to help support these high-risk patients. To best allocate resources, it is important to identify those young adults most vulnerable to drop out. Here we report on the success of our clinic and factors affecting failure to transition. Methods This was a retrospective chart review of patients seen in the NM/LCH transition clinic from 2014 to 2022. Demographic and clinical data of diagnosis, zip code, distance from clinic, average household income, parental/caregiver presence, working/school status, no-show rate, insurance, and baseline kidney function were collected. For those who successfully transitioned, data on prompt communications were also collected. Results Overall, 92% of patients successfully transitioned to adult care. 27% of patients missed their first adult center appointment and required execution of a prompt protocol. After this intervention, an additional 19% of patients successfully transitioned. 39% of those who failed to transition had a primary diagnosis of hypertension as compared to only 9% in those who transitioned successfully. Those who successfully transitioned had a lower mean estimated glomerular filtration rate of 89 mL/min/1.73 m² as compared to 116 mL/min/1.73 m² in the group who failed to transition. 15% of those who failed to transition lacked insurance as compared to only 1% of patients who successfully transitioned. Finally, those who required prompts had a significantly higher no-show rate at the pediatric center at 10% as compared to 6% in those not requiring prompts. Conclusion Transition clinics can help promote the successful transition from pediatric to adult nephrology care. Higher kidney function, lack of insurance, and primary diagnosis of hypertension were significantly correlated with failure to transition, and a higher pediatric center no-show rate was significantly correlated with the need for prompts in this single-center study. Clinical trial number Not applicable.https://doi.org/10.1186/s12882-025-04225-wChronic kidney diseasePediatric nephrologyTransition of careRisk factorsTransition clinic |
| spellingShingle | Laura Nishi Jay Kang Cybele Ghossein Predictors of failure to transition from pediatric to adult nephrology care BMC Nephrology Chronic kidney disease Pediatric nephrology Transition of care Risk factors Transition clinic |
| title | Predictors of failure to transition from pediatric to adult nephrology care |
| title_full | Predictors of failure to transition from pediatric to adult nephrology care |
| title_fullStr | Predictors of failure to transition from pediatric to adult nephrology care |
| title_full_unstemmed | Predictors of failure to transition from pediatric to adult nephrology care |
| title_short | Predictors of failure to transition from pediatric to adult nephrology care |
| title_sort | predictors of failure to transition from pediatric to adult nephrology care |
| topic | Chronic kidney disease Pediatric nephrology Transition of care Risk factors Transition clinic |
| url | https://doi.org/10.1186/s12882-025-04225-w |
| work_keys_str_mv | AT lauranishi predictorsoffailuretotransitionfrompediatrictoadultnephrologycare AT jaykang predictorsoffailuretotransitionfrompediatrictoadultnephrologycare AT cybeleghossein predictorsoffailuretotransitionfrompediatrictoadultnephrologycare |