Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities
Inflammation is recognized as an important factor in the pathophysiology of hypertension, with the renin-angiotensin-aldosterone system (RAAS) playing a key role in the disease. Initially described because of its contribution to extracellular fluid and electrolyte homeostasis, the RAAS has been impl...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/829786 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849410779172831232 |
|---|---|
| author | Daniel Arthur B. Kasal Ernesto L. Schiffrin |
| author_facet | Daniel Arthur B. Kasal Ernesto L. Schiffrin |
| author_sort | Daniel Arthur B. Kasal |
| collection | DOAJ |
| description | Inflammation is recognized as an important factor in the pathophysiology of hypertension, with the renin-angiotensin-aldosterone system (RAAS) playing a key role in the disease. Initially described because of its contribution to extracellular fluid and electrolyte homeostasis, the RAAS has been implicated in endothelial dysfunction, vascular remodeling, oxidative stress, proinflammatory cytokine production, and adhesion molecule synthesis by the vascular wall. Both angiotensin II and aldosterone are involved in these systemic effects, activating innate and adaptive immune responses. This paper highlights some aspects connecting RAAS to the hypertensive phenotype, based on experimental and clinical studies, with emphasis on new findings regarding the contribution of an increasingly studied population of T lymphocytes: the T-regulatory lymphocytes. These cells can suppress inflammation and may exert beneficial vascular effects in animal models of hypertension. |
| format | Article |
| id | doaj-art-5aadc4242cc248d6bb297d870537795e |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-5aadc4242cc248d6bb297d870537795e2025-08-20T03:34:58ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/829786829786Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic OpportunitiesDaniel Arthur B. Kasal0Ernesto L. Schiffrin1Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Avenida. 28 de Setembro 77, 3o.andar, Sala 329, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Medicine and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, CanadaInflammation is recognized as an important factor in the pathophysiology of hypertension, with the renin-angiotensin-aldosterone system (RAAS) playing a key role in the disease. Initially described because of its contribution to extracellular fluid and electrolyte homeostasis, the RAAS has been implicated in endothelial dysfunction, vascular remodeling, oxidative stress, proinflammatory cytokine production, and adhesion molecule synthesis by the vascular wall. Both angiotensin II and aldosterone are involved in these systemic effects, activating innate and adaptive immune responses. This paper highlights some aspects connecting RAAS to the hypertensive phenotype, based on experimental and clinical studies, with emphasis on new findings regarding the contribution of an increasingly studied population of T lymphocytes: the T-regulatory lymphocytes. These cells can suppress inflammation and may exert beneficial vascular effects in animal models of hypertension.http://dx.doi.org/10.1155/2012/829786 |
| spellingShingle | Daniel Arthur B. Kasal Ernesto L. Schiffrin Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities International Journal of Hypertension |
| title | Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities |
| title_full | Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities |
| title_fullStr | Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities |
| title_full_unstemmed | Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities |
| title_short | Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities |
| title_sort | angiotensin ii aldosterone and anti inflammatory lymphocytes interplay and therapeutic opportunities |
| url | http://dx.doi.org/10.1155/2012/829786 |
| work_keys_str_mv | AT danielarthurbkasal angiotensiniialdosteroneandantiinflammatorylymphocytesinterplayandtherapeuticopportunities AT ernestolschiffrin angiotensiniialdosteroneandantiinflammatorylymphocytesinterplayandtherapeuticopportunities |