A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia
Background: The evaluation of antiviral or vaccination strategies for the prevention of dengue infections in a traveler population would require extensive and complex studies. This prospective study aimed to identify a cohort of dengue naïve participants living in Medellín, a dengue endemic area, as...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/13/7/748 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849419003656667136 |
|---|---|
| author | Andrea Trujillo Liesbeth Van Wesenbeeck Lina Salazar Liliana López Lotke Tambuyzer Annemie Buelens Kim De Clerck Oliver Lenz Leen Vijgen Marnix Van Loock Guillermo Herrera-Taracena Iván Darío Vélez Freya Rasschaert |
| author_facet | Andrea Trujillo Liesbeth Van Wesenbeeck Lina Salazar Liliana López Lotke Tambuyzer Annemie Buelens Kim De Clerck Oliver Lenz Leen Vijgen Marnix Van Loock Guillermo Herrera-Taracena Iván Darío Vélez Freya Rasschaert |
| author_sort | Andrea Trujillo |
| collection | DOAJ |
| description | Background: The evaluation of antiviral or vaccination strategies for the prevention of dengue infections in a traveler population would require extensive and complex studies. This prospective study aimed to identify a cohort of dengue naïve participants living in Medellín, a dengue endemic area, as a proxy for travelers and to determine the incidence of primary dengue virus (DENV) infection (symptomatic and asymptomatic) in this cohort. In Colombia, epidemic dengue waves occur every 3–4 years, with infected <i>Aedes</i> mosquitoes present in ~80% of the territory, including Medellín. Methods: Participants > 16 years of age, living in Medellín, were screened for anti-DENV immunoglobulin G (IgG). DENV seronegative participants were enrolled in this study. A serological anti-DENV survey was performed, with semiannual sample collections for up to 2 years. Acute DENV infections were evaluated by monitoring fever and testing for DENV nonstructural protein 1 and/or RNA. Results: Of the 4885 screened participants, 3008 participants (62%) were DENV seronegative and enrolled. Among them, 2263 (75%) completed this study, and 2644 (88%) had at least one serosurvey visit after baseline. Of those, 52 (2%) had laboratory-confirmed DENV seroconversion, and 19 (<1%) had febrile illness, but none had laboratory-confirmed DENV infection. Conclusions: This study identified a cohort of predominantly students, seronegative at study start, living in Medellín and serving as a proxy for a prospective DENV infection traveler population. Laboratory-confirmed primary DENV infection was found in 2% of participants, with <1% reporting febrile illnesses, meeting the WHO criteria for probable clinical dengue cases. |
| format | Article |
| id | doaj-art-5aa0997ce15e4d47aac20d8c72fc00aa |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-5aa0997ce15e4d47aac20d8c72fc00aa2025-08-20T03:32:16ZengMDPI AGVaccines2076-393X2025-07-0113774810.3390/vaccines13070748A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, ColombiaAndrea Trujillo0Liesbeth Van Wesenbeeck1Lina Salazar2Liliana López3Lotke Tambuyzer4Annemie Buelens5Kim De Clerck6Oliver Lenz7Leen Vijgen8Marnix Van Loock9Guillermo Herrera-Taracena10Iván Darío Vélez11Freya Rasschaert12Grupo de Investigación Clínica-PECET (GIC-PECET), Universidad de Antioquia, Medellín 050010, AN, ColombiaJohnson & Johnson, 2340 Beerse, BelgiumGrupo de Investigación Clínica-PECET (GIC-PECET), Universidad de Antioquia, Medellín 050010, AN, ColombiaGrupo de Investigación Clínica-PECET (GIC-PECET), Universidad de Antioquia, Medellín 050010, AN, ColombiaJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, Horsham, PA 19044, USAPrograma de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Medellín 050010, AN, ColombiaJohnson & Johnson, 2340 Beerse, BelgiumBackground: The evaluation of antiviral or vaccination strategies for the prevention of dengue infections in a traveler population would require extensive and complex studies. This prospective study aimed to identify a cohort of dengue naïve participants living in Medellín, a dengue endemic area, as a proxy for travelers and to determine the incidence of primary dengue virus (DENV) infection (symptomatic and asymptomatic) in this cohort. In Colombia, epidemic dengue waves occur every 3–4 years, with infected <i>Aedes</i> mosquitoes present in ~80% of the territory, including Medellín. Methods: Participants > 16 years of age, living in Medellín, were screened for anti-DENV immunoglobulin G (IgG). DENV seronegative participants were enrolled in this study. A serological anti-DENV survey was performed, with semiannual sample collections for up to 2 years. Acute DENV infections were evaluated by monitoring fever and testing for DENV nonstructural protein 1 and/or RNA. Results: Of the 4885 screened participants, 3008 participants (62%) were DENV seronegative and enrolled. Among them, 2263 (75%) completed this study, and 2644 (88%) had at least one serosurvey visit after baseline. Of those, 52 (2%) had laboratory-confirmed DENV seroconversion, and 19 (<1%) had febrile illness, but none had laboratory-confirmed DENV infection. Conclusions: This study identified a cohort of predominantly students, seronegative at study start, living in Medellín and serving as a proxy for a prospective DENV infection traveler population. Laboratory-confirmed primary DENV infection was found in 2% of participants, with <1% reporting febrile illnesses, meeting the WHO criteria for probable clinical dengue cases.https://www.mdpi.com/2076-393X/13/7/748dengue virusdengue naïvetraveler’s populationseroconversionColombia |
| spellingShingle | Andrea Trujillo Liesbeth Van Wesenbeeck Lina Salazar Liliana López Lotke Tambuyzer Annemie Buelens Kim De Clerck Oliver Lenz Leen Vijgen Marnix Van Loock Guillermo Herrera-Taracena Iván Darío Vélez Freya Rasschaert A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia Vaccines dengue virus dengue naïve traveler’s population seroconversion Colombia |
| title | A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia |
| title_full | A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia |
| title_fullStr | A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia |
| title_full_unstemmed | A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia |
| title_short | A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia |
| title_sort | prospective cohort study of primary dengue virus infection in medellin colombia |
| topic | dengue virus dengue naïve traveler’s population seroconversion Colombia |
| url | https://www.mdpi.com/2076-393X/13/7/748 |
| work_keys_str_mv | AT andreatrujillo aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT liesbethvanwesenbeeck aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT linasalazar aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT lilianalopez aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT lotketambuyzer aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT annemiebuelens aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT kimdeclerck aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT oliverlenz aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT leenvijgen aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT marnixvanloock aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT guillermoherrerataracena aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT ivandariovelez aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT freyarasschaert aprospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT andreatrujillo prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT liesbethvanwesenbeeck prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT linasalazar prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT lilianalopez prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT lotketambuyzer prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT annemiebuelens prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT kimdeclerck prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT oliverlenz prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT leenvijgen prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT marnixvanloock prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT guillermoherrerataracena prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT ivandariovelez prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia AT freyarasschaert prospectivecohortstudyofprimarydenguevirusinfectioninmedellincolombia |