Interaction of tissue inhibitor of metalloproteinase 3 gene polymorphism, blood cadmium and total urinary arsenic levels on clear cell renal cell carcinoma

Interaction of tissue inhibitor of metalloproteinase 3 gene polymorphism, blood cadmium and total urinary arsenic levels on clear cell renal cell carcinoma

Abstract In renal cell carcinoma (RCC), tissue inhibitor of metalloproteinase (TIMP) 3 expression is lost, suggesting that the TIMP3 gene may function as a tumor suppressor gene. Cadmium (Cd) and arsenic (As) exposure may affect the expression of TIMP3. Here we investigate the association of clear c...

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Bibliographic Details
Main Authors: Chao-Yuan Huang, Mei-Chieh Chen, Chih-Yin Wu, Ying-Chin Lin, Ya-Li Huang, Horng-Sheng Shiue, Yeong-Shiau Pu, Yu-Mei Hsueh
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Tissue inhibitor of metalloproteinases 3
Cadmium
Arsenic
Clear Cell Renal cell carcinoma
Online Access:https://doi.org/10.1038/s41598-025-94807-3
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