Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and experimental validation

Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and experimental validation

ObjectiveThis study aimed to apply network pharmacology to identify the active components and key targets of Tongqiao Huashuan Granules in vascular dementia (VaD) and to evaluate its effects on autophagy in hippocampal neurons of VaD rats through animal testing.Materials and methodsThis study first...

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Bibliographic Details
Main Authors: Xiaoqu Jiang, Shuyao Yu, Shuaifeng Yao, Sikai Wang, Jing Cai, Zhongsheng Tang, Shijie Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neurology
Subjects:
Tongqiao Huashuan Granules
vascular dementia
PI3K/AKT/mTOR
autophagy
mechanism of action
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1555411/full
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