Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

<h4>Background</h4>The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and or...

Full description

Saved in:
Bibliographic Details
Main Authors: Valerie C Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M Grimshaw, Dan G Hackam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001489
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items