Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We?
In men aged less than 60, the association of serum and urinary levels of biochemical bone turnover markers (BTMs) and bone mineral density (BMD) is weak or not significant. After this age, higher BTM levels are correlated weakly, but significantly, with lower BMD and faster bone loss. Limited data f...
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| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/704015 |
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| author | Pawel Szulc |
| author_facet | Pawel Szulc |
| author_sort | Pawel Szulc |
| collection | DOAJ |
| description | In men aged less than 60, the association of serum and urinary levels of biochemical bone turnover markers (BTMs) and bone mineral density (BMD) is weak or not significant. After this age, higher BTM levels are correlated weakly, but significantly, with lower BMD and faster bone loss. Limited data from the cohort studies suggest that BTM measurement does not improve the prediction of fragility fractures in older men in comparison with age, BMD, history of falls and fragility fractures. Testosterone replacement therapy (TRT) decreases bone resorption. During TRT, bone formation markers slightly increase (direct effect on osteoblasts), then decrease (slowdown of bone turnover). Bisphosphonates (alendronate, risedronate, ibandronate, zoledronate) induce a rapid decrease in bone resorption followed by a milder decrease in bone formation. In men receiving antiresorptive therapy for prostate cancer, zoledronate, denosumab and toremifene decrease significantly levels of bone resorption and bone formation markers. Teriparatide induced a rapid increase in serum concentrations of bone formation markers followed by an increase in bone resorption. We need more studies on the utility of BTM measurement for the improvement of the persistence and adherence to the anti-osteoporotic treatment in men. |
| format | Article |
| id | doaj-art-5a9bcbe48ebc4406b4f70a8f7390b49c |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-5a9bcbe48ebc4406b4f70a8f7390b49c2025-02-03T05:54:17ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/704015704015Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We?Pawel Szulc0INSERM UMR 1033, Université de Lyon, Hôpital Edouard Herriot, Pavillon F, Place d'Arsonval, 69437 Lyon, FranceIn men aged less than 60, the association of serum and urinary levels of biochemical bone turnover markers (BTMs) and bone mineral density (BMD) is weak or not significant. After this age, higher BTM levels are correlated weakly, but significantly, with lower BMD and faster bone loss. Limited data from the cohort studies suggest that BTM measurement does not improve the prediction of fragility fractures in older men in comparison with age, BMD, history of falls and fragility fractures. Testosterone replacement therapy (TRT) decreases bone resorption. During TRT, bone formation markers slightly increase (direct effect on osteoblasts), then decrease (slowdown of bone turnover). Bisphosphonates (alendronate, risedronate, ibandronate, zoledronate) induce a rapid decrease in bone resorption followed by a milder decrease in bone formation. In men receiving antiresorptive therapy for prostate cancer, zoledronate, denosumab and toremifene decrease significantly levels of bone resorption and bone formation markers. Teriparatide induced a rapid increase in serum concentrations of bone formation markers followed by an increase in bone resorption. We need more studies on the utility of BTM measurement for the improvement of the persistence and adherence to the anti-osteoporotic treatment in men.http://dx.doi.org/10.4061/2011/704015 |
| spellingShingle | Pawel Szulc Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? Journal of Osteoporosis |
| title | Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? |
| title_full | Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? |
| title_fullStr | Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? |
| title_full_unstemmed | Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? |
| title_short | Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? |
| title_sort | biochemical bone turnover markers and osteoporosis in older men where are we |
| url | http://dx.doi.org/10.4061/2011/704015 |
| work_keys_str_mv | AT pawelszulc biochemicalboneturnovermarkersandosteoporosisinoldermenwherearewe |