Crosstalk between renin and arachidonic acid (and its metabolites)
Abstract Renin plays a significant role in the regulation of blood pressure and fluid volume by modulating the renin‒angiotensin‒aldosterone (RAAS) system. Renin suppression reduces serum aldosterone levels and lowers blood pressure in addition to preserving renal function. However, exactly how reni...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02463-3 |
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| author | Undurti N. Das Ahmet Hacimüftüoglu Erol Akpinar Mustafa Gul A. M. Abd El-Aty |
| author_facet | Undurti N. Das Ahmet Hacimüftüoglu Erol Akpinar Mustafa Gul A. M. Abd El-Aty |
| author_sort | Undurti N. Das |
| collection | DOAJ |
| description | Abstract Renin plays a significant role in the regulation of blood pressure and fluid volume by modulating the renin‒angiotensin‒aldosterone (RAAS) system. Renin suppression reduces serum aldosterone levels and lowers blood pressure in addition to preserving renal function. However, exactly how renin synthesis and action are regulated and how renin suppression preserves renal function are not clear. We propose that arachidonic acid (AA) and its metabolites control renin synthesis, secretion, and action by virtue of its (AA) anti-inflammatory, cytoprotective actions and ability to regulate the secretion of renin. These findings suggest that direct renin suppression results in changes in AA metabolism. This proposal implies that AA and its metabolites may be developed as potential drugs to prevent and manage hypertension and preserve renal function. |
| format | Article |
| id | doaj-art-5a8e6690d35344b4a692e290c836f0e5 |
| institution | DOAJ |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-5a8e6690d35344b4a692e290c836f0e52025-08-20T03:10:54ZengBMCLipids in Health and Disease1476-511X2025-02-0124111610.1186/s12944-025-02463-3Crosstalk between renin and arachidonic acid (and its metabolites)Undurti N. Das0Ahmet Hacimüftüoglu1Erol Akpinar2Mustafa Gul3A. M. Abd El-Aty4UND Life SciencesDepartment of Medical Pharmacology, Medical Faculty, Ataturk UniversityDepartment of Medical Pharmacology, Medical Faculty, Ataturk UniversityDepartment of Physiology, Faculty of Medicine, Ataturk UniversityDepartment of Medical Pharmacology, Medical Faculty, Ataturk UniversityAbstract Renin plays a significant role in the regulation of blood pressure and fluid volume by modulating the renin‒angiotensin‒aldosterone (RAAS) system. Renin suppression reduces serum aldosterone levels and lowers blood pressure in addition to preserving renal function. However, exactly how renin synthesis and action are regulated and how renin suppression preserves renal function are not clear. We propose that arachidonic acid (AA) and its metabolites control renin synthesis, secretion, and action by virtue of its (AA) anti-inflammatory, cytoprotective actions and ability to regulate the secretion of renin. These findings suggest that direct renin suppression results in changes in AA metabolism. This proposal implies that AA and its metabolites may be developed as potential drugs to prevent and manage hypertension and preserve renal function.https://doi.org/10.1186/s12944-025-02463-3ReninRenin-angiotensin-aldosterone systemInflammationArachidonic acidNitric oxideNeurotransmitters |
| spellingShingle | Undurti N. Das Ahmet Hacimüftüoglu Erol Akpinar Mustafa Gul A. M. Abd El-Aty Crosstalk between renin and arachidonic acid (and its metabolites) Lipids in Health and Disease Renin Renin-angiotensin-aldosterone system Inflammation Arachidonic acid Nitric oxide Neurotransmitters |
| title | Crosstalk between renin and arachidonic acid (and its metabolites) |
| title_full | Crosstalk between renin and arachidonic acid (and its metabolites) |
| title_fullStr | Crosstalk between renin and arachidonic acid (and its metabolites) |
| title_full_unstemmed | Crosstalk between renin and arachidonic acid (and its metabolites) |
| title_short | Crosstalk between renin and arachidonic acid (and its metabolites) |
| title_sort | crosstalk between renin and arachidonic acid and its metabolites |
| topic | Renin Renin-angiotensin-aldosterone system Inflammation Arachidonic acid Nitric oxide Neurotransmitters |
| url | https://doi.org/10.1186/s12944-025-02463-3 |
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