Pharmacodynamics of interspecies interactions in polymicrobial infections
Abstract The pharmacodynamic response of bacterial pathogens to antibiotics can be influenced by interactions with other bacterial species in polymicrobial infections (PMIs). Understanding the complex eco-evolutionary dynamics of PMIs and their impact on antimicrobial treatment response represents a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00621-6 |
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| _version_ | 1832585988523687936 |
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| author | C. Herzberg J. G. C. van Hasselt |
| author_facet | C. Herzberg J. G. C. van Hasselt |
| author_sort | C. Herzberg |
| collection | DOAJ |
| description | Abstract The pharmacodynamic response of bacterial pathogens to antibiotics can be influenced by interactions with other bacterial species in polymicrobial infections (PMIs). Understanding the complex eco-evolutionary dynamics of PMIs and their impact on antimicrobial treatment response represents a step towards developing improved treatment strategies for PMIs. Here, we investigated how interspecies interactions in a multi-species bacterial community affect the pharmacodynamic response to antimicrobial treatment. To this end, we developed an in silico model which combined agent-based modeling with ordinary differential equations. Our analyses suggest that both interspecies interactions, modifying either drug sensitivity or bacterial growth rate, and drug-specific pharmacological properties drive the bacterial pharmacodynamic response. Furthermore, lifestyle of the bacterial population and the range of interactions can influence the impact of species interactions. In conclusion, this study provides a foundation for the design of antimicrobial treatment strategies for PMIs which leverage the effects of interspecies interactions. |
| format | Article |
| id | doaj-art-5a89d3ec815e41fc8beeb523bed258e3 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-5a89d3ec815e41fc8beeb523bed258e32025-01-26T12:17:50ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-01-0111111410.1038/s41522-024-00621-6Pharmacodynamics of interspecies interactions in polymicrobial infectionsC. Herzberg0J. G. C. van Hasselt1Leiden Academic Centre for Drug Research, Leiden UniversityLeiden Academic Centre for Drug Research, Leiden UniversityAbstract The pharmacodynamic response of bacterial pathogens to antibiotics can be influenced by interactions with other bacterial species in polymicrobial infections (PMIs). Understanding the complex eco-evolutionary dynamics of PMIs and their impact on antimicrobial treatment response represents a step towards developing improved treatment strategies for PMIs. Here, we investigated how interspecies interactions in a multi-species bacterial community affect the pharmacodynamic response to antimicrobial treatment. To this end, we developed an in silico model which combined agent-based modeling with ordinary differential equations. Our analyses suggest that both interspecies interactions, modifying either drug sensitivity or bacterial growth rate, and drug-specific pharmacological properties drive the bacterial pharmacodynamic response. Furthermore, lifestyle of the bacterial population and the range of interactions can influence the impact of species interactions. In conclusion, this study provides a foundation for the design of antimicrobial treatment strategies for PMIs which leverage the effects of interspecies interactions.https://doi.org/10.1038/s41522-024-00621-6 |
| spellingShingle | C. Herzberg J. G. C. van Hasselt Pharmacodynamics of interspecies interactions in polymicrobial infections npj Biofilms and Microbiomes |
| title | Pharmacodynamics of interspecies interactions in polymicrobial infections |
| title_full | Pharmacodynamics of interspecies interactions in polymicrobial infections |
| title_fullStr | Pharmacodynamics of interspecies interactions in polymicrobial infections |
| title_full_unstemmed | Pharmacodynamics of interspecies interactions in polymicrobial infections |
| title_short | Pharmacodynamics of interspecies interactions in polymicrobial infections |
| title_sort | pharmacodynamics of interspecies interactions in polymicrobial infections |
| url | https://doi.org/10.1038/s41522-024-00621-6 |
| work_keys_str_mv | AT cherzberg pharmacodynamicsofinterspeciesinteractionsinpolymicrobialinfections AT jgcvanhasselt pharmacodynamicsofinterspeciesinteractionsinpolymicrobialinfections |