Cytokine status’ pattern in acute period of ischemic stroke subtypes
Purpose The aim of this study was to assess a different pattern of inflammatory mediators in relation of ischemic stroke subtypes in acute period. Materials and Methods. The study involved 482 patients with different ischemic stroke (IS) subtypes. We studied the content of inflammatory interleuki...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2017-06-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/100766/97160 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850253285534990336 |
|---|---|
| author | S. I. Shkrobot N. R. Sokhor L. S. Milevska-Vovchuk L. V. Shkrobot |
| author_facet | S. I. Shkrobot N. R. Sokhor L. S. Milevska-Vovchuk L. V. Shkrobot |
| author_sort | S. I. Shkrobot |
| collection | DOAJ |
| description | Purpose The aim of this study was to assess a different pattern of inflammatory mediators in relation of ischemic stroke subtypes in acute period.
Materials and Methods. The study involved 482 patients with different ischemic stroke (IS) subtypes. We studied the content of inflammatory interleukins (IL-1β, IL-2, IL-6, IL-8, CRP, TNF-α) and anti-inflammatory interleukin IL-10 in blood serum.
Results The study revealed increasing content of pro-inflammatory cytokines in acute period of IS subtypes, especially at Large Artery AtheroSclerosis (LAAS) and CardioEmbolic Infarct (CEI). In patients with LAAS the level of IL-2, IL-6 and CRP was significantly higher compared to other IS subtypes. The content of IL-10 was significantly lower compared to patients with Undetermined Etiology (UDE) stroke and LACunar (LAC) stroke. We established the relationship between the concentration of IL-1β and IL-6 with the severity of LAAS, CEI and UDE on the 1st day of stroke. On the 7th day the concentration of IL-1β and IL-8 was significantly decreased at LAC, IL-2 – at LAC and LAAS, IL-6 and TNF-α at LAC and UDE. At LAAS the content of inflammatory mediators depended on the degree of arteries stenosis, the presence of unstable atherosclerotic plaques, the intima-media thickness. We found a direct relationship between the severity of LAAS and CEI on the 14th day with the CRP concentration on the 1st day (at LAAS – (r = 0.73, p = 0.003), at CEI – (r = 0.71, p = 0.002), indicating predictive value of CRP-content on the course of acute period of IS subtypes. We established the dependence between cardiac morphometric parameters with the level of pro-inflammatory interleukins in acute period of UDE. We found the relation between the content of IL-1β, IL-6 with left ventricular myocardial mass index at UDE.
Conclusions The content of inflammatory mediators in acute period of ischemic stroke depends on the pathogenic subtype of stroke. |
| format | Article |
| id | doaj-art-5a861817fa1a40c988eb50bcc1362377 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-5a861817fa1a40c988eb50bcc13623772025-08-20T01:57:25ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102017-06-01329329810.14739/2310-1210.2017.3.100766Cytokine status’ pattern in acute period of ischemic stroke subtypesS. I. ShkrobotN. R. Sokhor L. S. Milevska-VovchukL. V. ShkrobotPurpose The aim of this study was to assess a different pattern of inflammatory mediators in relation of ischemic stroke subtypes in acute period. Materials and Methods. The study involved 482 patients with different ischemic stroke (IS) subtypes. We studied the content of inflammatory interleukins (IL-1β, IL-2, IL-6, IL-8, CRP, TNF-α) and anti-inflammatory interleukin IL-10 in blood serum. Results The study revealed increasing content of pro-inflammatory cytokines in acute period of IS subtypes, especially at Large Artery AtheroSclerosis (LAAS) and CardioEmbolic Infarct (CEI). In patients with LAAS the level of IL-2, IL-6 and CRP was significantly higher compared to other IS subtypes. The content of IL-10 was significantly lower compared to patients with Undetermined Etiology (UDE) stroke and LACunar (LAC) stroke. We established the relationship between the concentration of IL-1β and IL-6 with the severity of LAAS, CEI and UDE on the 1st day of stroke. On the 7th day the concentration of IL-1β and IL-8 was significantly decreased at LAC, IL-2 – at LAC and LAAS, IL-6 and TNF-α at LAC and UDE. At LAAS the content of inflammatory mediators depended on the degree of arteries stenosis, the presence of unstable atherosclerotic plaques, the intima-media thickness. We found a direct relationship between the severity of LAAS and CEI on the 14th day with the CRP concentration on the 1st day (at LAAS – (r = 0.73, p = 0.003), at CEI – (r = 0.71, p = 0.002), indicating predictive value of CRP-content on the course of acute period of IS subtypes. We established the dependence between cardiac morphometric parameters with the level of pro-inflammatory interleukins in acute period of UDE. We found the relation between the content of IL-1β, IL-6 with left ventricular myocardial mass index at UDE. Conclusions The content of inflammatory mediators in acute period of ischemic stroke depends on the pathogenic subtype of stroke.http://zmj.zsmu.edu.ua/article/view/100766/97160strokeinflammation mediators |
| spellingShingle | S. I. Shkrobot N. R. Sokhor L. S. Milevska-Vovchuk L. V. Shkrobot Cytokine status’ pattern in acute period of ischemic stroke subtypes Zaporožskij Medicinskij Žurnal stroke inflammation mediators |
| title | Cytokine status’ pattern in acute period of ischemic stroke subtypes |
| title_full | Cytokine status’ pattern in acute period of ischemic stroke subtypes |
| title_fullStr | Cytokine status’ pattern in acute period of ischemic stroke subtypes |
| title_full_unstemmed | Cytokine status’ pattern in acute period of ischemic stroke subtypes |
| title_short | Cytokine status’ pattern in acute period of ischemic stroke subtypes |
| title_sort | cytokine status pattern in acute period of ischemic stroke subtypes |
| topic | stroke inflammation mediators |
| url | http://zmj.zsmu.edu.ua/article/view/100766/97160 |
| work_keys_str_mv | AT sishkrobot cytokinestatuspatterninacuteperiodofischemicstrokesubtypes AT nrsokhor cytokinestatuspatterninacuteperiodofischemicstrokesubtypes AT lsmilevskavovchuk cytokinestatuspatterninacuteperiodofischemicstrokesubtypes AT lvshkrobot cytokinestatuspatterninacuteperiodofischemicstrokesubtypes |