Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation
Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity condi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/631951 |
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| author | Xiao-Hua Luo Ying-Jun Chang Xiao-Jun Huang |
| author_facet | Xiao-Hua Luo Ying-Jun Chang Xiao-Jun Huang |
| author_sort | Xiao-Hua Luo |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D−/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection. |
| format | Article |
| id | doaj-art-5a7df4f3468b470084c94a49cd010b2b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5a7df4f3468b470084c94a49cd010b2b2025-02-03T05:52:33ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/631951631951Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell TransplantationXiao-Hua Luo0Ying-Jun Chang1Xiao-Jun Huang2Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 Xizhimen South Street, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 Xizhimen South Street, Beijing 100044, ChinaCytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D−/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.http://dx.doi.org/10.1155/2014/631951 |
| spellingShingle | Xiao-Hua Luo Ying-Jun Chang Xiao-Jun Huang Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation Journal of Immunology Research |
| title | Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation |
| title_full | Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation |
| title_fullStr | Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation |
| title_full_unstemmed | Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation |
| title_short | Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation |
| title_sort | improving cytomegalovirus specific t cell reconstitution after haploidentical stem cell transplantation |
| url | http://dx.doi.org/10.1155/2014/631951 |
| work_keys_str_mv | AT xiaohualuo improvingcytomegalovirusspecifictcellreconstitutionafterhaploidenticalstemcelltransplantation AT yingjunchang improvingcytomegalovirusspecifictcellreconstitutionafterhaploidenticalstemcelltransplantation AT xiaojunhuang improvingcytomegalovirusspecifictcellreconstitutionafterhaploidenticalstemcelltransplantation |