Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy
In this review, the beneficial effects of metabolic therapy with propionyl L-carnitine (PPLC) on cardiovascular complications during the development of diabetic cardiomyopathy was evaluated. Since metabolic abnormalities due to mitochondrial dysfunction are invariably associated with deficiency of c...
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2025-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503557K.pdf |
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| author | Kaur Khushman Kirshenbaum Lorrie Tappia Paramjit S Dhalla Naranjan S |
| author_facet | Kaur Khushman Kirshenbaum Lorrie Tappia Paramjit S Dhalla Naranjan S |
| author_sort | Kaur Khushman |
| collection | DOAJ |
| description | In this review, the beneficial effects of metabolic therapy with propionyl L-carnitine (PPLC) on cardiovascular complications during the development of diabetic cardiomyopathy was evaluated. Since metabolic abnormalities due to mitochondrial dysfunction are invariably associated with deficiency of carnitine, accumulation of toxic long-chain derivatives of fatty acids and development of oxidative stress in the heart, it appears that the effects of PPLC therapy are related to the attenuation of these derangements. Particularly, the beneficial effects of PPLC therapy in improving cardiac function in chronic diabetes were associated with attenuation of increase in sarcolemmal Ca2+-binding and Ca2+-ecto ATPase activities. Furthermore, depressed sarcolemmal Na+-K+ ATPase and Na+-dependent Ca2+-uptake as well as sarcoplasmic reticulum Ca2+-pump activities in diabetic hearts were attenuated by PPLC therapy. These actions of PPLC therapy were accompanied by improvement in mitochondrial oxidative phosphorylation and attenuation of changes in the high energy phosphate stores in the diabetic heart. Since incubation of sarcolemma with PPLC was found to reduce the inhibitory actions of palmitoyl L-carnitine on Na+-K+ ATPases and Na+-dependent Ca2+-uptake, it is suggested that PPLC therapy may attenuate cardiac abnormalities by antagonising the deleterious actions of accumulated longchain lipids in diabetic cardiomyopathy. |
| format | Article |
| id | doaj-art-5a7ca2130e264b0f9f9abf6b025d1d4a |
| institution | Kabale University |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-5a7ca2130e264b0f9f9abf6b025d1d4a2025-08-20T03:56:38ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542025-01-0156355756510.5937/scriptamed56-595992490-33292503557KBeneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathyKaur Khushman0https://orcid.org/0009-0002-7013-3231Kirshenbaum Lorrie1https://orcid.org/0000-0002-9617-5803Tappia Paramjit S2https://orcid.org/0000-0001-8307-2760Dhalla Naranjan S3https://orcid.org/0000-0002-4894-4727University of Manitoba, Max Rady College of Medicine, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, Winnipeg, CanadaUniversity of Manitoba, Max Rady College of Medicine, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, Winnipeg, CanadaSt. Boniface Hospital, Asper Clinical Research Institute, Winnipeg, CanadaUniversity of Manitoba, Max Rady College of Medicine, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, Winnipeg, CanadaIn this review, the beneficial effects of metabolic therapy with propionyl L-carnitine (PPLC) on cardiovascular complications during the development of diabetic cardiomyopathy was evaluated. Since metabolic abnormalities due to mitochondrial dysfunction are invariably associated with deficiency of carnitine, accumulation of toxic long-chain derivatives of fatty acids and development of oxidative stress in the heart, it appears that the effects of PPLC therapy are related to the attenuation of these derangements. Particularly, the beneficial effects of PPLC therapy in improving cardiac function in chronic diabetes were associated with attenuation of increase in sarcolemmal Ca2+-binding and Ca2+-ecto ATPase activities. Furthermore, depressed sarcolemmal Na+-K+ ATPase and Na+-dependent Ca2+-uptake as well as sarcoplasmic reticulum Ca2+-pump activities in diabetic hearts were attenuated by PPLC therapy. These actions of PPLC therapy were accompanied by improvement in mitochondrial oxidative phosphorylation and attenuation of changes in the high energy phosphate stores in the diabetic heart. Since incubation of sarcolemma with PPLC was found to reduce the inhibitory actions of palmitoyl L-carnitine on Na+-K+ ATPases and Na+-dependent Ca2+-uptake, it is suggested that PPLC therapy may attenuate cardiac abnormalities by antagonising the deleterious actions of accumulated longchain lipids in diabetic cardiomyopathy.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503557K.pdfdiabetic cardiomyopathiespropionyl l-carnitinepalmitoyl l-carnitineoxidative stresssarcolemmasarcoplasmic reticulummitochondria |
| spellingShingle | Kaur Khushman Kirshenbaum Lorrie Tappia Paramjit S Dhalla Naranjan S Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy Scripta Medica diabetic cardiomyopathies propionyl l-carnitine palmitoyl l-carnitine oxidative stress sarcolemma sarcoplasmic reticulum mitochondria |
| title | Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy |
| title_full | Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy |
| title_fullStr | Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy |
| title_full_unstemmed | Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy |
| title_short | Beneficial effects of propionyl L-carnitine therapy in diabetic cardiomyopathy |
| title_sort | beneficial effects of propionyl l carnitine therapy in diabetic cardiomyopathy |
| topic | diabetic cardiomyopathies propionyl l-carnitine palmitoyl l-carnitine oxidative stress sarcolemma sarcoplasmic reticulum mitochondria |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503557K.pdf |
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