Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity
Objective: To assess the frequency of metabolic syndrome (MetS) in various rheumatic diseases and to depict its association with disease characteristics, activity, and/or severity. Methods: Two hundred fifty-seven patients [47 rheumatoid arthritis (RA), 100 systemic lupus erythematosus (SLE), 49 sy...
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Turkish Society for Rheumatology
2025-03-01
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| Series: | Ulusal Romatoloji Dergisi |
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| Online Access: | https://www.raeddergisi.org/articles/frequency-and-clinical-implications-of-metabolic-syndrome-in-different-rheumatic-diseases-relationship-with-disease-activity-and-severity/doi/raed.galenos.2025.27247 |
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| author | Suzan Sadek Al-Adle Passant Nabil El-Husseiny Nahla Naeem Eesa Tamer A Gheita |
| author_facet | Suzan Sadek Al-Adle Passant Nabil El-Husseiny Nahla Naeem Eesa Tamer A Gheita |
| author_sort | Suzan Sadek Al-Adle |
| collection | DOAJ |
| description | Objective: To assess the frequency of metabolic syndrome (MetS) in various rheumatic diseases and to depict its association with disease characteristics, activity, and/or severity.
Methods: Two hundred fifty-seven patients [47 rheumatoid arthritis (RA), 100 systemic lupus erythematosus (SLE), 49 systemic sclerosis (SSc), 33 axial spondyloarthritis (axSpA), and 28 vasculitis (21 with primary vasculitis and 7 with Behçet’s disease (BD)] and 70 controls were recruited, with a suitable number of controls matched for each corresponding disease. Demographic data, body mass index, waist circumference, comorbidities, and clinical and laboratory data were collected. Disease activity and/or severity were determined. MetS was defined according to the Adult Treatment Panel criteria.
Results: In RA, MetS was comparable to the control group with no significant association to the disease activity score (p=0.33), but there was a significant difference according to the activity grading (p=0.007). In SLE, MetS was significantly more frequent (42%) versus the control (14.9%) (p=0.001) and was significantly related to disease activity (p=0.001). In SSc, axSpA, and vasculitis, the frequency of MetS was comparable to their corresponding controls (p=0.24, p=0.4, p=0.08) and was not related to their disease activity scores (p=0.7, p=0.4, p=0.97; respectively), as well as p=0.45 and p=0.14 for BD activity and damage. When comparing the different rheumatic diseases, MetS was significantly more frequent in SLE (p=0.04). Regarding MetS components, there was a significantly higher frequency of hypertension (p<0.0001) and significantly higher triglycerides (p=0.004) in SLE versus the other rheumatic diseases. No significant association was found between neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with MetS in RA (p=0.4, p=0.4), SLE (p=0.35, p=0.73), SSc (p=0.46, p=0.14), axSpA (p=0.35, p=0.45) and vasculitis (p=0.72, p=0.29).
Conclusion: MetS is frequently associated with rheumatic diseases, being significantly more frequent in SLE, and could be related to disease activity. |
| format | Article |
| id | doaj-art-5a7bf78e85a140f183d187ea7d3edfa1 |
| institution | DOAJ |
| issn | 2651-2653 2651-2661 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Turkish Society for Rheumatology |
| record_format | Article |
| series | Ulusal Romatoloji Dergisi |
| spelling | doaj-art-5a7bf78e85a140f183d187ea7d3edfa12025-08-20T02:41:11ZengTurkish Society for RheumatologyUlusal Romatoloji Dergisi2651-26532651-26612025-03-01171202910.4274/raed.galenos.2025.27247Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severitySuzan Sadek Al-Adle0https://orcid.org/0000-0002-7200-1083Passant Nabil El-Husseiny1https://orcid.org/0000-0002-1503-7071Nahla Naeem Eesa2https://orcid.org/0000-0001-6981-3470Tamer A Gheita3https://orcid.org/0000-0002-1155-9729Cairo University Faculty of Medicine Department of Rheumatology, Cairo, EgyptCairo University Faculty of Medicine Department of Rheumatology, Cairo, EgyptCairo University Faculty of Medicine Department of Rheumatology, Cairo, EgyptCairo University Faculty of Medicine Department of Rheumatology, Cairo, EgyptObjective: To assess the frequency of metabolic syndrome (MetS) in various rheumatic diseases and to depict its association with disease characteristics, activity, and/or severity. Methods: Two hundred fifty-seven patients [47 rheumatoid arthritis (RA), 100 systemic lupus erythematosus (SLE), 49 systemic sclerosis (SSc), 33 axial spondyloarthritis (axSpA), and 28 vasculitis (21 with primary vasculitis and 7 with Behçet’s disease (BD)] and 70 controls were recruited, with a suitable number of controls matched for each corresponding disease. Demographic data, body mass index, waist circumference, comorbidities, and clinical and laboratory data were collected. Disease activity and/or severity were determined. MetS was defined according to the Adult Treatment Panel criteria. Results: In RA, MetS was comparable to the control group with no significant association to the disease activity score (p=0.33), but there was a significant difference according to the activity grading (p=0.007). In SLE, MetS was significantly more frequent (42%) versus the control (14.9%) (p=0.001) and was significantly related to disease activity (p=0.001). In SSc, axSpA, and vasculitis, the frequency of MetS was comparable to their corresponding controls (p=0.24, p=0.4, p=0.08) and was not related to their disease activity scores (p=0.7, p=0.4, p=0.97; respectively), as well as p=0.45 and p=0.14 for BD activity and damage. When comparing the different rheumatic diseases, MetS was significantly more frequent in SLE (p=0.04). Regarding MetS components, there was a significantly higher frequency of hypertension (p<0.0001) and significantly higher triglycerides (p=0.004) in SLE versus the other rheumatic diseases. No significant association was found between neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with MetS in RA (p=0.4, p=0.4), SLE (p=0.35, p=0.73), SSc (p=0.46, p=0.14), axSpA (p=0.35, p=0.45) and vasculitis (p=0.72, p=0.29). Conclusion: MetS is frequently associated with rheumatic diseases, being significantly more frequent in SLE, and could be related to disease activity.https://www.raeddergisi.org/articles/frequency-and-clinical-implications-of-metabolic-syndrome-in-different-rheumatic-diseases-relationship-with-disease-activity-and-severity/doi/raed.galenos.2025.27247rheumatic diseasesmetabolic syndrome (mets)disease activityseverity |
| spellingShingle | Suzan Sadek Al-Adle Passant Nabil El-Husseiny Nahla Naeem Eesa Tamer A Gheita Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity Ulusal Romatoloji Dergisi rheumatic diseases metabolic syndrome (mets) disease activity severity |
| title | Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity |
| title_full | Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity |
| title_fullStr | Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity |
| title_full_unstemmed | Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity |
| title_short | Frequency and clinical implications of metabolic syndrome in different rheumatic diseases: Relationship with disease activity and severity |
| title_sort | frequency and clinical implications of metabolic syndrome in different rheumatic diseases relationship with disease activity and severity |
| topic | rheumatic diseases metabolic syndrome (mets) disease activity severity |
| url | https://www.raeddergisi.org/articles/frequency-and-clinical-implications-of-metabolic-syndrome-in-different-rheumatic-diseases-relationship-with-disease-activity-and-severity/doi/raed.galenos.2025.27247 |
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