Quality of life and clinical data in hemodialysis patients with different degrees of pruritus
Abstract Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, its possible association with selected solutes, and impact on quality of life (QoL) in hemodialysis patients. Involvin...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83833-2 |
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| author | Sebastián Mas Fontao Paula Manso Julia Audije-Gil David Hernán Gascueña Fabiola Dapena Nuria Aresté Emilio Sánchez-Álvarez Pablo Molina Raquel Ojeda Marian Goicoechea Vicent Esteve Simó Guillermo Alcalde Bezhold Mario Prieto-Velasco María Jesús Lloret Ana Blanco Santos Juan Manuel Buades Carlos Narváez Rafael Sánchez-Villanueva Rosa Elena Pérez-Morales María Dolores Arenas Jiménez Fundación Renal Española Working Group Prurito Working Group |
| author_facet | Sebastián Mas Fontao Paula Manso Julia Audije-Gil David Hernán Gascueña Fabiola Dapena Nuria Aresté Emilio Sánchez-Álvarez Pablo Molina Raquel Ojeda Marian Goicoechea Vicent Esteve Simó Guillermo Alcalde Bezhold Mario Prieto-Velasco María Jesús Lloret Ana Blanco Santos Juan Manuel Buades Carlos Narváez Rafael Sánchez-Villanueva Rosa Elena Pérez-Morales María Dolores Arenas Jiménez Fundación Renal Española Working Group Prurito Working Group |
| author_sort | Sebastián Mas Fontao |
| collection | DOAJ |
| description | Abstract Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, its possible association with selected solutes, and impact on quality of life (QoL) in hemodialysis patients. Involving 434 hemodialysis patients in Spain, this observational study employed a survey based on validated pruritus assessment tools, alongside demographic, clinical, and biochemical data collection. The study used statistical analyses to examine the correlation between CKD-aP and various QoL dimensions. CKD-aP affected 46,4% (202) of the participants, with no significant variation across gender and age (p = 0.222 and p = 0.379, respectively). There were no significant associations between CKD-aP and biochemical markers like calcium, phosphate, and C-reactive protein (p > 0.05, in all cases). Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). The nighttime report exhibited the most significant differences, as more than half of the patients with moderate to severe pruritus reported constant and frequent itching (23.0% and 27.9%, respectively). Concerning other variables and symptoms associated with QoL, pruritus group exhibited higher rates of anxiety, depression, decreased sexual desire and sexual function, and sometimes to most of the time reported sleep onset problems, sleeping pill use, and drowsiness on waking (p < 0.001 in all cases). When stratifying by pruritus intensity differences persisted across anxiety (p < 0.001) and sleep onset problems (p = 0.018). The findings underscore the high prevalence and severe impact of CKD-aP in QoL among hemodialysis patients, indicating a need for standardized screening and treatment approaches in clinical practice. The lack of correlation with common biochemical markers suggests an intricate pathophysiology, warranting further investigation. These insights emphasize the necessity of holistic management strategies and more research to understand CKD-aP complex nature for better patient outcomes. |
| format | Article |
| id | doaj-art-5a7b702d369b43db8910de42fdbd6ba0 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-5a7b702d369b43db8910de42fdbd6ba02025-08-20T03:10:50ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-024-83833-2Quality of life and clinical data in hemodialysis patients with different degrees of pruritusSebastián Mas Fontao0Paula Manso1Julia Audije-Gil2David Hernán Gascueña3Fabiola Dapena4Nuria Aresté5Emilio Sánchez-Álvarez6Pablo Molina7Raquel Ojeda8Marian Goicoechea9Vicent Esteve Simó10Guillermo Alcalde Bezhold11Mario Prieto-Velasco12María Jesús Lloret13Ana Blanco Santos14Juan Manuel Buades15Carlos Narváez16Rafael Sánchez-Villanueva17Rosa Elena Pérez-Morales18María Dolores Arenas Jiménez19Fundación Renal Española Working GroupPrurito Working GroupIIS-Fundación Jiménez DíazUnidad de Investigación, Fundación Renal EspañolaUnidad de Investigación, Fundación Renal EspañolaUnidad de Investigación, Fundación Renal EspañolaUnidad de Investigación, Fundación Renal EspañolaDepartment of Nephrology, Hospital Universitario Virgen MacarenaDepartment of Nephrology, Hospital Universitario de CabueñesDepartment of Nephrology, Hospital Universitario Dr PesetServicio de Nefrología, Hospital Universitario Renia SofíaServicio de Nefrología, Hospital General Universitario Gregorio MarañónServicio de Nefrología, Consorci Sanitari de TarrasaServicio de Nefrología, Hospital Universitario de ArabaDepartment of Nephrology, Complejo Asistencial Universitario de LeónFundación PuigvertDepartment of Nephrology, Fresenius Medical Care Diálisis AlcobendasNephrology, Hospital Son Llatzer, Fundació Institut d’Investigació Sanitària Illes BalearsColman, Centro Médico de EspecialidadesDepartment of Nephrology, Hospital Universitario La PazDepartment of Nephrology, Hospital Universitario Nuestra Senora de la CandelariaUnidad de Investigación, Fundación Renal EspañolaAbstract Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, its possible association with selected solutes, and impact on quality of life (QoL) in hemodialysis patients. Involving 434 hemodialysis patients in Spain, this observational study employed a survey based on validated pruritus assessment tools, alongside demographic, clinical, and biochemical data collection. The study used statistical analyses to examine the correlation between CKD-aP and various QoL dimensions. CKD-aP affected 46,4% (202) of the participants, with no significant variation across gender and age (p = 0.222 and p = 0.379, respectively). There were no significant associations between CKD-aP and biochemical markers like calcium, phosphate, and C-reactive protein (p > 0.05, in all cases). Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). The nighttime report exhibited the most significant differences, as more than half of the patients with moderate to severe pruritus reported constant and frequent itching (23.0% and 27.9%, respectively). Concerning other variables and symptoms associated with QoL, pruritus group exhibited higher rates of anxiety, depression, decreased sexual desire and sexual function, and sometimes to most of the time reported sleep onset problems, sleeping pill use, and drowsiness on waking (p < 0.001 in all cases). When stratifying by pruritus intensity differences persisted across anxiety (p < 0.001) and sleep onset problems (p = 0.018). The findings underscore the high prevalence and severe impact of CKD-aP in QoL among hemodialysis patients, indicating a need for standardized screening and treatment approaches in clinical practice. The lack of correlation with common biochemical markers suggests an intricate pathophysiology, warranting further investigation. These insights emphasize the necessity of holistic management strategies and more research to understand CKD-aP complex nature for better patient outcomes.https://doi.org/10.1038/s41598-024-83833-2Biochemical markersChronic kidney diseaseCKD-aPSexualityPsychosocial disorders |
| spellingShingle | Sebastián Mas Fontao Paula Manso Julia Audije-Gil David Hernán Gascueña Fabiola Dapena Nuria Aresté Emilio Sánchez-Álvarez Pablo Molina Raquel Ojeda Marian Goicoechea Vicent Esteve Simó Guillermo Alcalde Bezhold Mario Prieto-Velasco María Jesús Lloret Ana Blanco Santos Juan Manuel Buades Carlos Narváez Rafael Sánchez-Villanueva Rosa Elena Pérez-Morales María Dolores Arenas Jiménez Fundación Renal Española Working Group Prurito Working Group Quality of life and clinical data in hemodialysis patients with different degrees of pruritus Scientific Reports Biochemical markers Chronic kidney disease CKD-aP Sexuality Psychosocial disorders |
| title | Quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| title_full | Quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| title_fullStr | Quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| title_full_unstemmed | Quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| title_short | Quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| title_sort | quality of life and clinical data in hemodialysis patients with different degrees of pruritus |
| topic | Biochemical markers Chronic kidney disease CKD-aP Sexuality Psychosocial disorders |
| url | https://doi.org/10.1038/s41598-024-83833-2 |
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