Toxoplasma TgCtwh3 Δrop16Ⅰ/Ⅲ accelerates neuronal apoptosis and APP production in mouse with acute infection

Toxoplasma TgCtwh3 Δrop16Ⅰ/Ⅲ accelerates neuronal apoptosis and APP production in mouse with acute infection

Objective: To explore the mechanism by which rop16Ⅰ/Ⅲ-deficient/gra15Ⅱ-dominant toxoplasma gondii Chinese 1 genotype Wh3 (TgCtwh3 Δrop16Ⅰ/Ⅲ) strain induced neuron apoptosis, APP and BACE1 production in vivo and vitro. Method: BALB/c mice were infected by intraperitoneal injection with TgCtwh3 wild t...

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Bibliographic Details
Main Authors: Di Yang, Cong Wang, Qing Tao, Lei Liu, Mengmeng Jin, Haiping Cai, Meijuan Zheng, Mengtao Gong, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Kunpeng Qin, Deyong Chu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
Subjects:
T.gondii Chinese 1 genotype Wh3 strain
ROP16Ⅰ/Ⅲ
Hippocampal neuron
Apoptosis
APP
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000752
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