Total Antioxidant Status in Type 2 Diabetic Patients in Palestine
The objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/461271 |
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| author | Akram T. Kharroubi Hisham M. Darwish Mutaz A. Akkawi Abdelkareem A. Ashareef Zaher A. Almasri Khaldoun A. Bader Umaiyeh M. Khammash |
| author_facet | Akram T. Kharroubi Hisham M. Darwish Mutaz A. Akkawi Abdelkareem A. Ashareef Zaher A. Almasri Khaldoun A. Bader Umaiyeh M. Khammash |
| author_sort | Akram T. Kharroubi |
| collection | DOAJ |
| description | The objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal body mass index (BMI) levels (<25), 29% were overweight (≥25 to <30), and 61.2% were obese (≥30). The mean levels of TAS were significantly higher in diabetic compared to control subjects (2.18 versus 1.84 mM Trolox, P = 0.001) and in hypertensive subjects compared to subjects with normal blood pressure (BP). Mean TAS levels were higher in obese compared to nonobese subjects (2.12 versus 1.85 mM Trolox, P = 0.001). Mean TAS levels were similarly higher in subjects with high fasting plasma glucose (FPG) compared to normal FPG (2.19 versus 1.90 mM Trolox) and high HbA1c (≥6.5%) compared to HbA1c < 6.5% (2.14 versus 1.91 mM Trolox). Multivariate analysis revealed that only diabetic status (P = 0.032) and the level of education (P = 0.036) were significantly associated with TAS. In conclusion diabetic patients had 18.5% increase in TAS levels compared to control subjects. |
| format | Article |
| id | doaj-art-5a77fdfdb22b4a3e961c0759e138110f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5a77fdfdb22b4a3e961c0759e138110f2025-02-03T07:24:33ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/461271461271Total Antioxidant Status in Type 2 Diabetic Patients in PalestineAkram T. Kharroubi0Hisham M. Darwish1Mutaz A. Akkawi2Abdelkareem A. Ashareef3Zaher A. Almasri4Khaldoun A. Bader5Umaiyeh M. Khammash6Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of PalestineDepartment of Biochemistry, Faculty of Medicine, Al-Quds University, Jerusalem, State of PalestineDepartment of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of PalestineDepartment of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of PalestineDepartment of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of PalestineFaculty of Public Health, Al-Quds University, Jerusalem, State of PalestineUnited Nation Relief and Works Agency (UNRWA), Jerusalem, State of PalestineThe objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal body mass index (BMI) levels (<25), 29% were overweight (≥25 to <30), and 61.2% were obese (≥30). The mean levels of TAS were significantly higher in diabetic compared to control subjects (2.18 versus 1.84 mM Trolox, P = 0.001) and in hypertensive subjects compared to subjects with normal blood pressure (BP). Mean TAS levels were higher in obese compared to nonobese subjects (2.12 versus 1.85 mM Trolox, P = 0.001). Mean TAS levels were similarly higher in subjects with high fasting plasma glucose (FPG) compared to normal FPG (2.19 versus 1.90 mM Trolox) and high HbA1c (≥6.5%) compared to HbA1c < 6.5% (2.14 versus 1.91 mM Trolox). Multivariate analysis revealed that only diabetic status (P = 0.032) and the level of education (P = 0.036) were significantly associated with TAS. In conclusion diabetic patients had 18.5% increase in TAS levels compared to control subjects.http://dx.doi.org/10.1155/2015/461271 |
| spellingShingle | Akram T. Kharroubi Hisham M. Darwish Mutaz A. Akkawi Abdelkareem A. Ashareef Zaher A. Almasri Khaldoun A. Bader Umaiyeh M. Khammash Total Antioxidant Status in Type 2 Diabetic Patients in Palestine Journal of Diabetes Research |
| title | Total Antioxidant Status in Type 2 Diabetic Patients in Palestine |
| title_full | Total Antioxidant Status in Type 2 Diabetic Patients in Palestine |
| title_fullStr | Total Antioxidant Status in Type 2 Diabetic Patients in Palestine |
| title_full_unstemmed | Total Antioxidant Status in Type 2 Diabetic Patients in Palestine |
| title_short | Total Antioxidant Status in Type 2 Diabetic Patients in Palestine |
| title_sort | total antioxidant status in type 2 diabetic patients in palestine |
| url | http://dx.doi.org/10.1155/2015/461271 |
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