The impact of innate immunity and epigenetics in the pathogenesis of hidradenitis suppurativa

The impact of innate immunity and epigenetics in the pathogenesis of hidradenitis suppurativa

Hidradenitis Suppurativa (HS) is a chronic multifactorial inflammatory skin disease with a debilitating impact on quality of life. Here, we review the complex interplay of innate and adaptive immune dysregulation in HS pathogenesis, in the context of microbial dysbiosis, genetic predisposition, cell...

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Main Authors: Olivia M. Burke, Victoria R. Frerichs, Dario F. Garcia, Rivka C. Stone, Hadar Lev-Tov, Tali Czarnowicki, Robert W. Keane, Nkemcho Ojeh, Jelena Marjanovic, Irena Pastar, Marjana Tomic-Canic, Juan Pablo de Rivero Vaccari, Andrew P. Sawaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
hidradenitis suppurativa
innate immunity
epigenetics
inflammasomes
inflammatory skin disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593253/full
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