Pth-carrying high-strength hydrogel promotes bone defect reconstruction via the PTH1R/SLPI pathway
The repair of bone defects, particularly those of a substantial size, has historically posed considerable challenges due to insufficient blood supply and the absence of attachment points. Hydrogels have seen a surge in applications in wound healing and drug delivery due to their exceptional biocompa...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525004137 |
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| Summary: | The repair of bone defects, particularly those of a substantial size, has historically posed considerable challenges due to insufficient blood supply and the absence of attachment points. Hydrogels have seen a surge in applications in wound healing and drug delivery due to their exceptional biocompatibility and biodegradability. In this study, a high-strength hydrogel (G/mA Gel) was developed to promote bone defect repair by loading parathyroid hormone (PTH). The PTH-G/mA Gel demonstrated the capacity to release PTH in a continuous and stable manner, thereby significantly enhancing the differentiation of MC3T3 osteoblasts. In a rat skull defect model, the bone density and bone volume of the PTH-G/mA gel group were significantly higher than those of the control group and the group using PTH alone. Subsequent analysis revealed that this enhancement was attributable to the slow-release mechanism of PTH, which exerted a synergistic effect on osteogenesis by activating the PTH1R/SLPI pathway in conjunction with the mechanical reinforcement provided by the hydrogel at the defect site. This study proposes a novel, cost-effective strategy with minimal adverse effects, providing a new avenue for the treatment of bone defects. |
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| ISSN: | 0264-1275 |