Behçet Disease-Like Symptoms with a Novel COPA Mutation
COPA syndrome is a recently described autosomal dominant disorder with key immune dysregulation caused by defects within the COPA gene. These mutations lead to endoplasmic reticulum stress and autoimmune response with upregulation of Th17 cytokines. The clinical phenotype of COPA syndrome primarily...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2020/8414857 |
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| _version_ | 1832567449366560768 |
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| author | E. Anderson J. Hatch J. Cardinal D. Langguth D. Coman |
| author_facet | E. Anderson J. Hatch J. Cardinal D. Langguth D. Coman |
| author_sort | E. Anderson |
| collection | DOAJ |
| description | COPA syndrome is a recently described autosomal dominant disorder with key immune dysregulation caused by defects within the COPA gene. These mutations lead to endoplasmic reticulum stress and autoimmune response with upregulation of Th17 cytokines. The clinical phenotype of COPA syndrome primarily comprised pulmonary disease, arthritis, and renal disease secondary to immune dysregulation, with onset of symptoms commonly in the first decade of life. Herein, we describe a family with an attenuated Behçet-like phenotype of COPA syndrome, further expanding the phenotypic understanding of this syndrome. |
| format | Article |
| id | doaj-art-5a74fe6d4a824399a0138c0f5446e77c |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-5a74fe6d4a824399a0138c0f5446e77c2025-02-03T01:01:26ZengWileyCase Reports in Genetics2090-65442090-65522020-01-01202010.1155/2020/84148578414857Behçet Disease-Like Symptoms with a Novel COPA MutationE. Anderson0J. Hatch1J. Cardinal2D. Langguth3D. Coman4Virtus Diagnostics, Brisbane, AustraliaDepartment of Paediatrics, The Wesley Hospital, Brisbane, AustraliaCardinal Bioresearch, Brisbane, AustraliaDepartment of Immunology, Sullivan Nicolaides Pathology, Brisbane, AustraliaVirtus Diagnostics, Brisbane, AustraliaCOPA syndrome is a recently described autosomal dominant disorder with key immune dysregulation caused by defects within the COPA gene. These mutations lead to endoplasmic reticulum stress and autoimmune response with upregulation of Th17 cytokines. The clinical phenotype of COPA syndrome primarily comprised pulmonary disease, arthritis, and renal disease secondary to immune dysregulation, with onset of symptoms commonly in the first decade of life. Herein, we describe a family with an attenuated Behçet-like phenotype of COPA syndrome, further expanding the phenotypic understanding of this syndrome.http://dx.doi.org/10.1155/2020/8414857 |
| spellingShingle | E. Anderson J. Hatch J. Cardinal D. Langguth D. Coman Behçet Disease-Like Symptoms with a Novel COPA Mutation Case Reports in Genetics |
| title | Behçet Disease-Like Symptoms with a Novel COPA Mutation |
| title_full | Behçet Disease-Like Symptoms with a Novel COPA Mutation |
| title_fullStr | Behçet Disease-Like Symptoms with a Novel COPA Mutation |
| title_full_unstemmed | Behçet Disease-Like Symptoms with a Novel COPA Mutation |
| title_short | Behçet Disease-Like Symptoms with a Novel COPA Mutation |
| title_sort | behcet disease like symptoms with a novel copa mutation |
| url | http://dx.doi.org/10.1155/2020/8414857 |
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