Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study
The aim of the study was to compare the clinical efficacy and safety of two antiviral therapy medications that suppress viral replication (viral RNA polymerase inhibitors) in the treatment of patients with COVID-19: favipiravir and riamilovir.Material and methods. Clinical efficacy and safety were a...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2024-04-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1107 |
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| author | A. U. Sabitov E. P. Tikhonova E. V. Esaulenko P. L. Kuznetsov A. A. Sharova T. A. Yelistratova Yu. S. Kalinina I. V. Andreeva V. V. Basina E. V. Oleinichenko A. S. Edin |
| author_facet | A. U. Sabitov E. P. Tikhonova E. V. Esaulenko P. L. Kuznetsov A. A. Sharova T. A. Yelistratova Yu. S. Kalinina I. V. Andreeva V. V. Basina E. V. Oleinichenko A. S. Edin |
| author_sort | A. U. Sabitov |
| collection | DOAJ |
| description | The aim of the study was to compare the clinical efficacy and safety of two antiviral therapy medications that suppress viral replication (viral RNA polymerase inhibitors) in the treatment of patients with COVID-19: favipiravir and riamilovir.Material and methods. Clinical efficacy and safety were assessed based on a retrospective study of 1071 patients, including 561 patients who received favipiravir and 510 patients who received riamilovir.Results. A statistically significant reduction in the duration of symptoms and average hospital days was recorded among patients who received ramilovir in both moderate and severe forms of the disease compared with the group that received favipiravir. Inflammatory markers (CRP, fibrinogen) decreased faster in the riamilovir group.Conclusion. Riamilovir has demonstrated higher levels of clinical efficacy and safety in the treatment of COVID-19 compared to favipiravir. |
| format | Article |
| id | doaj-art-5a6f0e82d0dd43d08ef8e22848dedffa |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-5a6f0e82d0dd43d08ef8e22848dedffa2025-08-20T02:49:33ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902024-04-01691-2374310.37489/0235-2990-2024-69-1-2-37-431017Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational studyA. U. Sabitov0E. P. Tikhonova1E. V. Esaulenko2P. L. Kuznetsov3A. A. Sharova4T. A. Yelistratova5Yu. S. Kalinina6I. V. Andreeva7V. V. Basina8E. V. Oleinichenko9A. S. Edin10Ural State Medical University of the Ministry of Health of the Russian FederationKrasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky of the Ministry of Health of the Russian FederationSaint Petersburg State Pediatric Medical University of the Ministry of Health of the Russian FederationUral State Medical University of the Ministry of Health of the Russian FederationUral State Medical University of the Ministry of Health of the Russian FederationKrasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky of the Ministry of Health of the Russian FederationKrasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky of the Ministry of Health of the Russian FederationCenter for the Prevention and Control of AIDS and Infectious DiseasesSaint Petersburg State Pediatric Medical University of the Ministry of Health of the Russian FederationPolyclinic No. 3 of the Administrative Directorate of the President of the Russian FederationJSC «Firsanovka Medicine»The aim of the study was to compare the clinical efficacy and safety of two antiviral therapy medications that suppress viral replication (viral RNA polymerase inhibitors) in the treatment of patients with COVID-19: favipiravir and riamilovir.Material and methods. Clinical efficacy and safety were assessed based on a retrospective study of 1071 patients, including 561 patients who received favipiravir and 510 patients who received riamilovir.Results. A statistically significant reduction in the duration of symptoms and average hospital days was recorded among patients who received ramilovir in both moderate and severe forms of the disease compared with the group that received favipiravir. Inflammatory markers (CRP, fibrinogen) decreased faster in the riamilovir group.Conclusion. Riamilovir has demonstrated higher levels of clinical efficacy and safety in the treatment of COVID-19 compared to favipiravir.https://www.antibiotics-chemotherapy.ru/jour/article/view/1107covid-19riamilovirefficiencysafety |
| spellingShingle | A. U. Sabitov E. P. Tikhonova E. V. Esaulenko P. L. Kuznetsov A. A. Sharova T. A. Yelistratova Yu. S. Kalinina I. V. Andreeva V. V. Basina E. V. Oleinichenko A. S. Edin Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study Антибиотики и Химиотерапия covid-19 riamilovir efficiency safety |
| title | Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study |
| title_full | Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study |
| title_fullStr | Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study |
| title_full_unstemmed | Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study |
| title_short | Efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of COVID-19. Results of a comparative retrospective observational study |
| title_sort | efficacy and safety of oral antiviral therapy medications in the treatment of moderate and severe cases of covid 19 results of a comparative retrospective observational study |
| topic | covid-19 riamilovir efficiency safety |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1107 |
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