Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis
Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple scleros...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/931574 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225116338716672 |
|---|---|
| author | Carlos Magno da Costa Maranduba Sandra Bertelli Ribeiro De Castro Gustavo Torres de Souza Cristiano Rossato Francisco Carlos da Guia Maria Anete Santana Valente João Vitor Paes Rettore Claudinéia Pereira Maranduba Camila Maurmann de Souza Antônio Márcio Resende do Carmo Gilson Costa Macedo Fernando de Sá Silva |
| author_facet | Carlos Magno da Costa Maranduba Sandra Bertelli Ribeiro De Castro Gustavo Torres de Souza Cristiano Rossato Francisco Carlos da Guia Maria Anete Santana Valente João Vitor Paes Rettore Claudinéia Pereira Maranduba Camila Maurmann de Souza Antônio Márcio Resende do Carmo Gilson Costa Macedo Fernando de Sá Silva |
| author_sort | Carlos Magno da Costa Maranduba |
| collection | DOAJ |
| description | Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work—gut microbiota, immune system, and their influence in the neuroimmune system. |
| format | Article |
| id | doaj-art-5a6ee22c8b0f45039e9fe3ee62f8fc1f |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5a6ee22c8b0f45039e9fe3ee62f8fc1f2025-08-20T02:05:28ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/931574931574Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and HomeostasisCarlos Magno da Costa Maranduba0Sandra Bertelli Ribeiro De Castro1Gustavo Torres de Souza2Cristiano Rossato3Francisco Carlos da Guia4Maria Anete Santana Valente5João Vitor Paes Rettore6Claudinéia Pereira Maranduba7Camila Maurmann de Souza8Antônio Márcio Resende do Carmo9Gilson Costa Macedo10Fernando de Sá Silva11Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, BrazilDepartment of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Immunology, University of São Paulo, São Paulo, BrazilDepartment of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Nutrition, Federal University of Juiz de Fora, Governador Valadares, BrazilDepartment of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Clinical Dentistry, Federal University of Juiz de Fora, Juiz de Fora, BrazilDepartment of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, BrazilDepartment of Dentistry, Federal University of Juiz de Fora, Governador Valadares, BrazilMany immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work—gut microbiota, immune system, and their influence in the neuroimmune system.http://dx.doi.org/10.1155/2015/931574 |
| spellingShingle | Carlos Magno da Costa Maranduba Sandra Bertelli Ribeiro De Castro Gustavo Torres de Souza Cristiano Rossato Francisco Carlos da Guia Maria Anete Santana Valente João Vitor Paes Rettore Claudinéia Pereira Maranduba Camila Maurmann de Souza Antônio Márcio Resende do Carmo Gilson Costa Macedo Fernando de Sá Silva Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis Journal of Immunology Research |
| title | Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis |
| title_full | Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis |
| title_fullStr | Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis |
| title_full_unstemmed | Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis |
| title_short | Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis |
| title_sort | intestinal microbiota as modulators of the immune system and neuroimmune system impact on the host health and homeostasis |
| url | http://dx.doi.org/10.1155/2015/931574 |
| work_keys_str_mv | AT carlosmagnodacostamaranduba intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT sandrabertelliribeirodecastro intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT gustavotorresdesouza intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT cristianorossato intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT franciscocarlosdaguia intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT mariaanetesantanavalente intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT joaovitorpaesrettore intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT claudineiapereiramaranduba intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT camilamaurmanndesouza intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT antoniomarcioresendedocarmo intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT gilsoncostamacedo intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis AT fernandodesasilva intestinalmicrobiotaasmodulatorsoftheimmunesystemandneuroimmunesystemimpactonthehosthealthandhomeostasis |