Ligusticum chuanxiong: a chemical, pharmacological and clinical review
Ethnopharmacological RelevanceThe dried rhizome of Ligusticum chuanxiong S.H.Qiu, Y.Q.Zeng, K.Y.Pan, Y.C.Tang and J.M.Xu (Apiaceae; including the horticultural variety Ligusticum chuanxiong Hort.) [synonym: Conioselinum anthriscoides (H.Boissieu) Pimenov and Kljuykov (The taxonomic classification ha...
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Frontiers Media S.A.
2025-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1523176/full |
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| author | Yin Wang Yin Wang Liuyun Wu Liuyun Wu Hulin Wang Hulin Wang Mingyu Jiang Yu Chen Xingyue Zheng Lian Li Qinan Yin Qinan Yin Lizhu Han Lizhu Han Lan Bai Lan Bai Yuan Bian Yuan Bian |
| author_facet | Yin Wang Yin Wang Liuyun Wu Liuyun Wu Hulin Wang Hulin Wang Mingyu Jiang Yu Chen Xingyue Zheng Lian Li Qinan Yin Qinan Yin Lizhu Han Lizhu Han Lan Bai Lan Bai Yuan Bian Yuan Bian |
| author_sort | Yin Wang |
| collection | DOAJ |
| description | Ethnopharmacological RelevanceThe dried rhizome of Ligusticum chuanxiong S.H.Qiu, Y.Q.Zeng, K.Y.Pan, Y.C.Tang and J.M.Xu (Apiaceae; including the horticultural variety Ligusticum chuanxiong Hort.) [synonym: Conioselinum anthriscoides (H.Boissieu) Pimenov and Kljuykov (The taxonomic classification has been adopted by the World Checklist of Vascular Plants)] is a traditional Chinese botanical drug renowned for its anti-inflammatory and antioxidant properties. It has been widely used to treatment various diseases, particularly cardio-cerebral vascular diseases (CCVDs).Aim of the reviewThis review aims to summarize recent advances in Ligusticum chuanxiong (CX) research, including its chemical composition and pharmacological effects, and modern clinical applications.Materials and methodsA systematic literature search was conducted using keywords such as “Chuanxiong,” “traditional Chinese medicine,” “chemical components,” “metabolites,” “CCVDs,” and “pharmacological effects” to identify relevant literature published between 2014 and 2025. Databases including PubMed, Web of Science, Google Scholar, and CNKI were utilized. Chemical structures in SMILES format were retrieved from the PubChem, and two-dimensional chemical structures were generated using ChemDraw Ultra 8.0. Classical prescriptions of chuanxiong were obtained from authoritative traditional Chinese medicine databases.ResultsOver 100 metabolites have been isolated and identified from CX, classified into nine major classes. Key bioactive compounds include senkyunolide A, ligustilide, tetramethylpyrazine (TMP), and ligusticum CX polysaccharides (LCP). CX demonstrates significant pharmacological effects in treating CCVDs, such as atherosclerosis (AS), myocardial and cerebral ischemia-reperfusion injury, and hypertension. Its therapeutic mechanisms include antiplatelet activity, endothelial cell protection, anti-inflammatory, antioxidant, and anti-apoptotic properties. CX can be administered alone or in combination with other traditional Chinese medicines (TCMs) or chemical drugs, showing efficacy in cardiovascular, nervous system, digestive system disorders, as well as analgesia and anticancer activities.ConclusionCX holds substantial clinical value for treating multi-system diseases, with extensive evidence supporting its use in CCVDs. Further research and clinical exploration of CX are warranted to fully harness its therapeutic potential. |
| format | Article |
| id | doaj-art-5a691eec8fc34c5cbc4e0c1de4250b08 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5a691eec8fc34c5cbc4e0c1de4250b082025-08-20T01:54:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15231761523176Ligusticum chuanxiong: a chemical, pharmacological and clinical reviewYin Wang0Yin Wang1Liuyun Wu2Liuyun Wu3Hulin Wang4Hulin Wang5Mingyu Jiang6Yu Chen7Xingyue Zheng8Lian Li9Qinan Yin10Qinan Yin11Lizhu Han12Lizhu Han13Lan Bai14Lan Bai15Yuan Bian16Yuan Bian17Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Pharmacy, North Sichuan Medical Collage, Nanchong, ChinaPower China Chengdu Engineering Corporation Limited, Chengdu, ChinaDepartment of Pharmacy, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, The Fourth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaEthnopharmacological RelevanceThe dried rhizome of Ligusticum chuanxiong S.H.Qiu, Y.Q.Zeng, K.Y.Pan, Y.C.Tang and J.M.Xu (Apiaceae; including the horticultural variety Ligusticum chuanxiong Hort.) [synonym: Conioselinum anthriscoides (H.Boissieu) Pimenov and Kljuykov (The taxonomic classification has been adopted by the World Checklist of Vascular Plants)] is a traditional Chinese botanical drug renowned for its anti-inflammatory and antioxidant properties. It has been widely used to treatment various diseases, particularly cardio-cerebral vascular diseases (CCVDs).Aim of the reviewThis review aims to summarize recent advances in Ligusticum chuanxiong (CX) research, including its chemical composition and pharmacological effects, and modern clinical applications.Materials and methodsA systematic literature search was conducted using keywords such as “Chuanxiong,” “traditional Chinese medicine,” “chemical components,” “metabolites,” “CCVDs,” and “pharmacological effects” to identify relevant literature published between 2014 and 2025. Databases including PubMed, Web of Science, Google Scholar, and CNKI were utilized. Chemical structures in SMILES format were retrieved from the PubChem, and two-dimensional chemical structures were generated using ChemDraw Ultra 8.0. Classical prescriptions of chuanxiong were obtained from authoritative traditional Chinese medicine databases.ResultsOver 100 metabolites have been isolated and identified from CX, classified into nine major classes. Key bioactive compounds include senkyunolide A, ligustilide, tetramethylpyrazine (TMP), and ligusticum CX polysaccharides (LCP). CX demonstrates significant pharmacological effects in treating CCVDs, such as atherosclerosis (AS), myocardial and cerebral ischemia-reperfusion injury, and hypertension. Its therapeutic mechanisms include antiplatelet activity, endothelial cell protection, anti-inflammatory, antioxidant, and anti-apoptotic properties. CX can be administered alone or in combination with other traditional Chinese medicines (TCMs) or chemical drugs, showing efficacy in cardiovascular, nervous system, digestive system disorders, as well as analgesia and anticancer activities.ConclusionCX holds substantial clinical value for treating multi-system diseases, with extensive evidence supporting its use in CCVDs. Further research and clinical exploration of CX are warranted to fully harness its therapeutic potential.https://www.frontiersin.org/articles/10.3389/fphar.2025.1523176/fullethnopharmacologyLigusticum chuanxiongtraditional Chinese medicinemetabolitepharmacological effectscardio-cerebral vascular diseases |
| spellingShingle | Yin Wang Yin Wang Liuyun Wu Liuyun Wu Hulin Wang Hulin Wang Mingyu Jiang Yu Chen Xingyue Zheng Lian Li Qinan Yin Qinan Yin Lizhu Han Lizhu Han Lan Bai Lan Bai Yuan Bian Yuan Bian Ligusticum chuanxiong: a chemical, pharmacological and clinical review Frontiers in Pharmacology ethnopharmacology Ligusticum chuanxiong traditional Chinese medicine metabolite pharmacological effects cardio-cerebral vascular diseases |
| title | Ligusticum chuanxiong: a chemical, pharmacological and clinical review |
| title_full | Ligusticum chuanxiong: a chemical, pharmacological and clinical review |
| title_fullStr | Ligusticum chuanxiong: a chemical, pharmacological and clinical review |
| title_full_unstemmed | Ligusticum chuanxiong: a chemical, pharmacological and clinical review |
| title_short | Ligusticum chuanxiong: a chemical, pharmacological and clinical review |
| title_sort | ligusticum chuanxiong a chemical pharmacological and clinical review |
| topic | ethnopharmacology Ligusticum chuanxiong traditional Chinese medicine metabolite pharmacological effects cardio-cerebral vascular diseases |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1523176/full |
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