The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis
Background and Aim: Infection caused by Pseudomonas aeruginosa (P. aeruginosa) with multiple drug resistance is one of the most important problems in patients suffering from cystic fibrosis. The purpose of this research is to investigate the prevalence of P. aeruginosa isolated with multiple drug re...
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Kurdistan University of Medical Sciences
2025-03-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
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| Online Access: | http://sjku.muk.ac.ir/article-1-7162-en.pdf |
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| author | Jalileh Ebn Abbas Samaneh Rouhi Hamed Jafarpour Khadijeh Taherkhani Sanaz Ahmadi Bijan Nouri Rasool Nasiri Kalmarzi Farshid Gholami Arya Jafari Nasrin Yaghoobi |
| author_facet | Jalileh Ebn Abbas Samaneh Rouhi Hamed Jafarpour Khadijeh Taherkhani Sanaz Ahmadi Bijan Nouri Rasool Nasiri Kalmarzi Farshid Gholami Arya Jafari Nasrin Yaghoobi |
| author_sort | Jalileh Ebn Abbas |
| collection | DOAJ |
| description | Background and Aim: Infection caused by Pseudomonas aeruginosa (P. aeruginosa) with multiple drug resistance is one of the most important problems in patients suffering from cystic fibrosis. The purpose of this research is to investigate the prevalence of P. aeruginosa isolated with multiple drug resistance in patients suffering from cystic fibrosis.
Materials and Methods: Articles between 2008 and 2022 were searched. To perform the meta-analysis, STATA 14 software was used both in the fixed model and in the random effects model. To check the heterogeneity of the data, the Q-test (p<0.10) was used with the chi-square χ2 distribution at the 95% confidence level. Two-sided statistical tests were performed with α=0.05.
Results: The highest (100%, 95% confidence interval (CI): 0.99-1.00) and the lowest (4%, 95% CI: 0.02-0.09) prevalence was in 2021. In cross-sectional studies, the prevalence of 44% (95% CI: 0.21-0.68, odds ratio (OR) = 1.55), and in the cohort, 52% (95% CI: 0.26-0.77, OR = 1.68) was observed. Prevalence of both age groups; <20 (95% CI: 0.09-0.97, OR = 1.7, p = 0.000) and ≥ 20 (95% CI: 76. 0.30-0.76, OR = 1.7, p = 0.000) was 53%.
Conclusion: Multiple drug resistance was observed in P. aeruginosa during different years and ages. The findings of this research and the increasing antibiotic resistance of this bacterium indicate the leading challenges in the treatment of patients with cystic fibrosis, which must be properly managed and treated. |
| format | Article |
| id | doaj-art-5a651d4a422449909170d4cf19a4b271 |
| institution | DOAJ |
| issn | 1560-652X 2345-4040 |
| language | fas |
| publishDate | 2025-03-01 |
| publisher | Kurdistan University of Medical Sciences |
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| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj-art-5a651d4a422449909170d4cf19a4b2712025-08-20T03:09:48ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402025-03-01301139160The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-AnalysisJalileh Ebn Abbas0Samaneh Rouhi1Hamed Jafarpour2Khadijeh Taherkhani3Sanaz Ahmadi4Bijan Nouri5Rasool Nasiri Kalmarzi6Farshid Gholami7Arya Jafari8Nasrin Yaghoobi9 MSc of Medical Microbiology, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran PhD of Medical Bacteriology, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran General Practitioner, Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran MSc of Medical Parasitology, Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran MSc of Medical Bacteriology, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran. Associate Professor of Biostatistics, Health Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Associate Professor of Pediatric Allergy and Immunology, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran General Practitioner Student, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran General Practitioner Student, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran General Practitioner Student, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran. Background and Aim: Infection caused by Pseudomonas aeruginosa (P. aeruginosa) with multiple drug resistance is one of the most important problems in patients suffering from cystic fibrosis. The purpose of this research is to investigate the prevalence of P. aeruginosa isolated with multiple drug resistance in patients suffering from cystic fibrosis. Materials and Methods: Articles between 2008 and 2022 were searched. To perform the meta-analysis, STATA 14 software was used both in the fixed model and in the random effects model. To check the heterogeneity of the data, the Q-test (p<0.10) was used with the chi-square χ2 distribution at the 95% confidence level. Two-sided statistical tests were performed with α=0.05. Results: The highest (100%, 95% confidence interval (CI): 0.99-1.00) and the lowest (4%, 95% CI: 0.02-0.09) prevalence was in 2021. In cross-sectional studies, the prevalence of 44% (95% CI: 0.21-0.68, odds ratio (OR) = 1.55), and in the cohort, 52% (95% CI: 0.26-0.77, OR = 1.68) was observed. Prevalence of both age groups; <20 (95% CI: 0.09-0.97, OR = 1.7, p = 0.000) and ≥ 20 (95% CI: 76. 0.30-0.76, OR = 1.7, p = 0.000) was 53%. Conclusion: Multiple drug resistance was observed in P. aeruginosa during different years and ages. The findings of this research and the increasing antibiotic resistance of this bacterium indicate the leading challenges in the treatment of patients with cystic fibrosis, which must be properly managed and treated.http://sjku.muk.ac.ir/article-1-7162-en.pdfmultidrug-resistant (mdr)pseudomonas aeruginosapatientscystic fibrosis |
| spellingShingle | Jalileh Ebn Abbas Samaneh Rouhi Hamed Jafarpour Khadijeh Taherkhani Sanaz Ahmadi Bijan Nouri Rasool Nasiri Kalmarzi Farshid Gholami Arya Jafari Nasrin Yaghoobi The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis مجله علمی دانشگاه علوم پزشکی کردستان multidrug-resistant (mdr) pseudomonas aeruginosa patients cystic fibrosis |
| title | The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis |
| title_full | The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis |
| title_fullStr | The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis |
| title_short | The Prevalence of Multidrug-Resistant (MDR) Pseudomonas aeruginosa Isolated from Patients Suffering from Cystic Fibrosis in the World: A Systematic Review and Meta-Analysis |
| title_sort | prevalence of multidrug resistant mdr pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis in the world a systematic review and meta analysis |
| topic | multidrug-resistant (mdr) pseudomonas aeruginosa patients cystic fibrosis |
| url | http://sjku.muk.ac.ir/article-1-7162-en.pdf |
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