Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation

Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation

Background: Bradykinin (BK), a 9–amino acid peptide, is a key mediator responsible for angioedema attacks in hereditary angioedema due to C1INH deficiency (HAE-C1INH). Current BK assays lack clinical utility due to the instability of BK (half-life < 30 seconds) and low pg/mL baseline levels. Obje...

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Bibliographic Details
Main Authors: Jinguo Chen, MD, Yunkou Wu, PhD, J. Joanna Yu, MD, PhD, Joseph Chiao, MD, Jing Yu, PhD, Mark D. Scarupa, MD, Lili Wan, PhD, H. Henry Li, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Hereditary angioedema
angioedema
bradykinin
plasma kallikrein
contact system
cold activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829325001067
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