A case of Hirschsprung disease: does thyroid hormone have any effect?
Hirschsprung disease, the colonization defect of neural crest cells through the colon, is one of the reasons for functional obstruction in neonates. Furthermore, hypothyroidism has been known to be one of the causes of bowel hypomotility and pseudoobstruction. These two diseases are generally...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2009-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2267 |
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| _version_ | 1850041745804361728 |
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| author | Makbule Eren Mustafa Celik Sibel Kinik Irfan Serdar Arda |
| author_facet | Makbule Eren Mustafa Celik Sibel Kinik Irfan Serdar Arda |
| author_sort | Makbule Eren |
| collection | DOAJ |
| description |
Hirschsprung disease, the colonization defect of neural crest cells through the colon, is one of the reasons for functional obstruction in neonates. Furthermore, hypothyroidism has been known to be one of the causes of bowel hypomotility and pseudoobstruction. These two diseases are generally considered in the differential diagnosis. Although defective thyroid function has been found to be responsible for inappropriate neuronal migration in the brain, the effect of thyroid hormone on neural crest cell migration to the bowel has not yet been evaluated. Here, we report a case with Hirschsprung disease and congenital hypothyroidism, which may point to the need for future studies evaluating the interaction of colonic neural crest cell colonization and thyroid hormone.
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| format | Article |
| id | doaj-art-5a63be1a78e34cb49e20ee5bfdc6659d |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2009-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-5a63be1a78e34cb49e20ee5bfdc6659d2025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212009-02-01511A case of Hirschsprung disease: does thyroid hormone have any effect?Makbule Eren0Mustafa CelikSibel KinikIrfan Serdar ArdaDepartment of Pediatrics, Osmangazi University Faculty of Medicine, Eskişehir, Turkey. Hirschsprung disease, the colonization defect of neural crest cells through the colon, is one of the reasons for functional obstruction in neonates. Furthermore, hypothyroidism has been known to be one of the causes of bowel hypomotility and pseudoobstruction. These two diseases are generally considered in the differential diagnosis. Although defective thyroid function has been found to be responsible for inappropriate neuronal migration in the brain, the effect of thyroid hormone on neural crest cell migration to the bowel has not yet been evaluated. Here, we report a case with Hirschsprung disease and congenital hypothyroidism, which may point to the need for future studies evaluating the interaction of colonic neural crest cell colonization and thyroid hormone. https://turkjpediatr.org/article/view/2267 |
| spellingShingle | Makbule Eren Mustafa Celik Sibel Kinik Irfan Serdar Arda A case of Hirschsprung disease: does thyroid hormone have any effect? The Turkish Journal of Pediatrics |
| title | A case of Hirschsprung disease: does thyroid hormone have any effect? |
| title_full | A case of Hirschsprung disease: does thyroid hormone have any effect? |
| title_fullStr | A case of Hirschsprung disease: does thyroid hormone have any effect? |
| title_full_unstemmed | A case of Hirschsprung disease: does thyroid hormone have any effect? |
| title_short | A case of Hirschsprung disease: does thyroid hormone have any effect? |
| title_sort | case of hirschsprung disease does thyroid hormone have any effect |
| url | https://turkjpediatr.org/article/view/2267 |
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