Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA
Background: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350124376 |
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| _version_ | 1849411791608610816 |
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| author | Marek P. Dąbrowski Wanda Stankiewicz Tadeusz Płusa Andrzej Chciałowski Stanisław Szmigielski |
| author_facet | Marek P. Dąbrowski Wanda Stankiewicz Tadeusz Płusa Andrzej Chciałowski Stanisław Szmigielski |
| author_sort | Marek P. Dąbrowski |
| collection | DOAJ |
| description | Background: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had accumulated in the culture medium. |
| format | Article |
| id | doaj-art-5a5caf9c847749d19e26552001e5cdfa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5a5caf9c847749d19e26552001e5cdfa2025-08-20T03:34:40ZengWileyMediators of Inflammation0962-93511466-18612001-01-0110310110710.1080/09629350124376Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHAMarek P. Dąbrowski0Wanda Stankiewicz1Tadeusz Płusa2Andrzej Chciałowski3Stanisław Szmigielski4Military Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, PolandMilitary Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, PolandCentral Clinical Hospital of Military Medical Academy, Clinic of Pneumonology and Allergy, Warsaw, PolandCentral Clinical Hospital of Military Medical Academy, Clinic of Pneumonology and Allergy, Warsaw, PolandMilitary Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, PolandBackground: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had accumulated in the culture medium.http://dx.doi.org/10.1080/09629350124376 |
| spellingShingle | Marek P. Dąbrowski Wanda Stankiewicz Tadeusz Płusa Andrzej Chciałowski Stanisław Szmigielski Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA Mediators of Inflammation |
| title | Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA |
| title_full | Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA |
| title_fullStr | Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA |
| title_full_unstemmed | Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA |
| title_short | Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA |
| title_sort | competition of il 1 and il 1ra determines lymphocyte response to delayed stimulation with pha |
| url | http://dx.doi.org/10.1080/09629350124376 |
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