NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS
The majority of epilepsy cases have their onset in childhood. Compared to their peers, many more children with epilepsy suffer from severe neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. In the present report, the incidence of intellectual disability an...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2018-02-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/372 |
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| author | N. N. Zavadenko |
| author_facet | N. N. Zavadenko |
| author_sort | N. N. Zavadenko |
| collection | DOAJ |
| description | The majority of epilepsy cases have their onset in childhood. Compared to their peers, many more children with epilepsy suffer from severe neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. In the present report, the incidence of intellectual disability and autism spectrum disorders among children with epilepsy is reviewed. Four types of connection between epilepsy and autism are discussed: these two conditions are independent as they have different etiologies and may co-occur just by chance; epilepsy and autism are associated because both originate from the same genetic defect or from an early CNS damage; autism is caused by the epileptic process, which interferes with the developing brain networks involved in communication and social behavior. Studies demonstrating positive effects of levetiracetam on the behavioral and cognitive functions (memory, attention) in epileptic children are cited. |
| format | Article |
| id | doaj-art-5a5c210c60fe45e59eb657a28902830c |
| institution | DOAJ |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-5a5c210c60fe45e59eb657a28902830c2025-08-20T03:19:34ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882018-02-0194647110.17749/2077-8333.2017.9.4.064-071359NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERSN. N. Zavadenko0N. I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaThe majority of epilepsy cases have their onset in childhood. Compared to their peers, many more children with epilepsy suffer from severe neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. In the present report, the incidence of intellectual disability and autism spectrum disorders among children with epilepsy is reviewed. Four types of connection between epilepsy and autism are discussed: these two conditions are independent as they have different etiologies and may co-occur just by chance; epilepsy and autism are associated because both originate from the same genetic defect or from an early CNS damage; autism is caused by the epileptic process, which interferes with the developing brain networks involved in communication and social behavior. Studies demonstrating positive effects of levetiracetam on the behavioral and cognitive functions (memory, attention) in epileptic children are cited.https://www.epilepsia.su/jour/article/view/372epilepsychildrenneurodevelopmental disordersepileptic encephalopathiesintellectual disabilityautism spectrum disorderslevetiracetam |
| spellingShingle | N. N. Zavadenko NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS Эпилепсия и пароксизмальные состояния epilepsy children neurodevelopmental disorders epileptic encephalopathies intellectual disability autism spectrum disorders levetiracetam |
| title | NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS |
| title_full | NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS |
| title_fullStr | NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS |
| title_full_unstemmed | NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS |
| title_short | NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS |
| title_sort | neurodevelopmental disorders in children with epilepsy intellectual disability and autism spectrum disorders |
| topic | epilepsy children neurodevelopmental disorders epileptic encephalopathies intellectual disability autism spectrum disorders levetiracetam |
| url | https://www.epilepsia.su/jour/article/view/372 |
| work_keys_str_mv | AT nnzavadenko neurodevelopmentaldisordersinchildrenwithepilepsyintellectualdisabilityandautismspectrumdisorders |