Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways
Anxiety and depression are common non-motor symptoms of Parkinson’s disease (PD) that significantly affect patients’ quality of life. In recent years, our understanding of PD has advanced through multifaceted studies on the pathological mechanisms associated with anxiety and depression in PD. These...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001422 |
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| author | Jihu Zhao Huafang Jia Pengju Ma Deyuan Zhu Yibin Fang |
| author_facet | Jihu Zhao Huafang Jia Pengju Ma Deyuan Zhu Yibin Fang |
| author_sort | Jihu Zhao |
| collection | DOAJ |
| description | Anxiety and depression are common non-motor symptoms of Parkinson’s disease (PD) that significantly affect patients’ quality of life. In recent years, our understanding of PD has advanced through multifaceted studies on the pathological mechanisms associated with anxiety and depression in PD. These classic psychiatric symptoms involve complex pathophysiology, with both distinct features and connections to the mechanisms underlying the aetiology of PD. Furthermore, the co-occurrence of anxiety and depression in PD blurs the boundaries between them. Therefore, a comprehensive summary of the pathogenic mechanisms associated with anxiety and depression will aid in better addressing the emergence of these classic psychiatric symptoms in PD. This article integrates neuroanatomical, neural projection, neurotransmitter, neuroinflammatory, brain-gut axis, neurotrophic, hypothalamic-pituitary-adrenal axis, and genetic perspectives to provide a comprehensive description of the core pathological alterations underlying anxiety and depression in PD, aiming to provide an up-to-date perspective and broader therapeutic prospects for PD patients suffering from anxiety or depression. |
| format | Article |
| id | doaj-art-5a5a1d22e63d445fab864e5cb80dfd8a |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-5a5a1d22e63d445fab864e5cb80dfd8a2025-08-20T03:14:08ZengElsevierPharmacological Research1096-11862025-05-0121510771710.1016/j.phrs.2025.107717Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathwaysJihu Zhao0Huafang Jia1Pengju Ma2Deyuan Zhu3Yibin Fang4Translational Research Institute of Brain and Brain-Like Intelligence, Department of Neurovascular Disease, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaQingdao Medical College of Qingdao University, Qingdao, Shandong, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, ChinaTranslational Research Institute of Brain and Brain-Like Intelligence, Department of Neurovascular Disease, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Corresponding authors.Translational Research Institute of Brain and Brain-Like Intelligence, Department of Neurovascular Disease, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Corresponding authors.Anxiety and depression are common non-motor symptoms of Parkinson’s disease (PD) that significantly affect patients’ quality of life. In recent years, our understanding of PD has advanced through multifaceted studies on the pathological mechanisms associated with anxiety and depression in PD. These classic psychiatric symptoms involve complex pathophysiology, with both distinct features and connections to the mechanisms underlying the aetiology of PD. Furthermore, the co-occurrence of anxiety and depression in PD blurs the boundaries between them. Therefore, a comprehensive summary of the pathogenic mechanisms associated with anxiety and depression will aid in better addressing the emergence of these classic psychiatric symptoms in PD. This article integrates neuroanatomical, neural projection, neurotransmitter, neuroinflammatory, brain-gut axis, neurotrophic, hypothalamic-pituitary-adrenal axis, and genetic perspectives to provide a comprehensive description of the core pathological alterations underlying anxiety and depression in PD, aiming to provide an up-to-date perspective and broader therapeutic prospects for PD patients suffering from anxiety or depression.http://www.sciencedirect.com/science/article/pii/S1043661825001422Parkinson’s diseaseAnxietyDepressionClinical imagingMolecular mechanismTargeted therapy |
| spellingShingle | Jihu Zhao Huafang Jia Pengju Ma Deyuan Zhu Yibin Fang Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways Pharmacological Research Parkinson’s disease Anxiety Depression Clinical imaging Molecular mechanism Targeted therapy |
| title | Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways |
| title_full | Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways |
| title_fullStr | Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways |
| title_full_unstemmed | Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways |
| title_short | Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways |
| title_sort | multidimensional mechanisms of anxiety and depression in parkinson s disease integrating neuroimaging neurocircuits and molecular pathways |
| topic | Parkinson’s disease Anxiety Depression Clinical imaging Molecular mechanism Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001422 |
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