Survival outcomes of marijuana users in p16 positive oropharynx cancer patients
Abstract Background Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. Despite...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-09-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s40463-019-0365-4 |
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| author | Han Zhang Michael Xie Marc Levin Stuart D. Archibald B. Stanley Jackson J. E. M. Young Michael K. Gupta |
| author_facet | Han Zhang Michael Xie Marc Levin Stuart D. Archibald B. Stanley Jackson J. E. M. Young Michael K. Gupta |
| author_sort | Han Zhang |
| collection | DOAJ |
| description | Abstract Background Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. Despite this, no study has examined the potential relationship between marijuana use and survival in this subset of patients. Objective To examine the survival outcomes of HPV-related OPSCC patients in marijuana users. Methods Patients who were marijuana users were identified from a prospectively collected database of HNC patients from January 2011 to 2015. A physical review of clinic records was undertaken to extract relevant patient, tumor, treatment, follow-up, as well as survival data. Patients greater than 17 years of age with pathologically proven p16 positive OPSCC were included. They were then case-matched in a 1-to-1 basis to patients who were non-marijuana users based on age, gender, and cTNM staging. Results Forty-Seven patients met inclusion criteria within each group. Univariate logistic regression analysis showed that age, gender, and cT-Stage were predictive of disease recurrence within both groups (p < 0.05). However, cN-stage, treatment modality, tumor subsite, tobacco use, and tobacco dose were not (p > 0.05). There was no statistically significant difference between marijuana and non-marijuana user groups in 5-year (p = 0.400) overall survival, disease-specific (p = 0.993), disease-free (p = 0.404), and metastasis-free survival (p = 0.384). Conclusions No survival difference is found between HPV-related OPSCC marijuana users and non-users. This finding has implications for both de-escalation regimes and the use of cannabis as a therapeutic agent. |
| format | Article |
| id | doaj-art-5a557d5c1b6a468591f3cd822de3fb49 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-5a557d5c1b6a468591f3cd822de3fb492025-02-03T00:22:58ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162019-09-014811610.1186/s40463-019-0365-4Survival outcomes of marijuana users in p16 positive oropharynx cancer patientsHan Zhang0Michael Xie1Marc Levin2Stuart D. Archibald3B. Stanley Jackson4J. E. M. Young5Michael K. Gupta6Division of Otolaryngology—Head and Neck Surgery, McMaster UniversityMichael DeGroote Faculty of Medicine, McMaster UniversityMichael DeGroote Faculty of Medicine, McMaster UniversityMichael DeGroote Faculty of Medicine, McMaster UniversityDivision of Otolaryngology—Head and Neck Surgery, McMaster UniversityDivision of Otolaryngology—Head and Neck Surgery, McMaster UniversityDivision of Otolaryngology—Head and Neck Surgery, McMaster UniversityAbstract Background Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. Despite this, no study has examined the potential relationship between marijuana use and survival in this subset of patients. Objective To examine the survival outcomes of HPV-related OPSCC patients in marijuana users. Methods Patients who were marijuana users were identified from a prospectively collected database of HNC patients from January 2011 to 2015. A physical review of clinic records was undertaken to extract relevant patient, tumor, treatment, follow-up, as well as survival data. Patients greater than 17 years of age with pathologically proven p16 positive OPSCC were included. They were then case-matched in a 1-to-1 basis to patients who were non-marijuana users based on age, gender, and cTNM staging. Results Forty-Seven patients met inclusion criteria within each group. Univariate logistic regression analysis showed that age, gender, and cT-Stage were predictive of disease recurrence within both groups (p < 0.05). However, cN-stage, treatment modality, tumor subsite, tobacco use, and tobacco dose were not (p > 0.05). There was no statistically significant difference between marijuana and non-marijuana user groups in 5-year (p = 0.400) overall survival, disease-specific (p = 0.993), disease-free (p = 0.404), and metastasis-free survival (p = 0.384). Conclusions No survival difference is found between HPV-related OPSCC marijuana users and non-users. This finding has implications for both de-escalation regimes and the use of cannabis as a therapeutic agent.http://link.springer.com/article/10.1186/s40463-019-0365-4Marijuanap16 positive oropharyngeal cancerSurvival outcomes |
| spellingShingle | Han Zhang Michael Xie Marc Levin Stuart D. Archibald B. Stanley Jackson J. E. M. Young Michael K. Gupta Survival outcomes of marijuana users in p16 positive oropharynx cancer patients Journal of Otolaryngology - Head and Neck Surgery Marijuana p16 positive oropharyngeal cancer Survival outcomes |
| title | Survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| title_full | Survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| title_fullStr | Survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| title_full_unstemmed | Survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| title_short | Survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| title_sort | survival outcomes of marijuana users in p16 positive oropharynx cancer patients |
| topic | Marijuana p16 positive oropharyngeal cancer Survival outcomes |
| url | http://link.springer.com/article/10.1186/s40463-019-0365-4 |
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