Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin
Coumarin is a natural substance isolated from different plants. It belonges to a group of benzobyrones which consists of a benzene ring joined to a pyrone nucleus. In the present research, a new series of coumarin derivatives were formed. Compound (1) (7-hydroxy-4-methyl Coumarin) was converted int...
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University of Baghdad, College of Science for Women
2016-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2769 |
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| description | Coumarin is a natural substance isolated from different plants. It belonges to a group of benzobyrones which consists of a benzene ring joined to a pyrone nucleus. In the present research, a new series of coumarin derivatives were formed. Compound (1) (7-hydroxy-4-methyl Coumarin) was converted into 4-methylquinolin-2(H) derivative (2) by reaction with acetamide, and then reaction of (2) with thiosemicarbazide in ethanol leads to the synthesize of hydrazincarbothioamide derivative (3).The reaction of (3) with ethylchloroacetate in presence of sodium acetate leads to closure ring to get [(1-(5-oxo-2-thioxoimidazolidin-1-ylimino) ethyl)]quinolin-2(1H)-one (4). Mannich bases were prepared through the reaction of (4) with primary amines to form compounds (5-6). New coumarin derivatives were characterized by their physical properties and various spectral analysis like: FTIR, 1HNMR spectra and GC-Mass spectrum for some of them. |
| format | Article |
| id | doaj-art-5a4b91b13bb043f69b2c5d9d08f6f5cf |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-5a4b91b13bb043f69b2c5d9d08f6f5cf2025-08-20T03:33:08ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-06-0113210.21123/bsj.13.2.235-243Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl CoumarinBaghdad Science JournalCoumarin is a natural substance isolated from different plants. It belonges to a group of benzobyrones which consists of a benzene ring joined to a pyrone nucleus. In the present research, a new series of coumarin derivatives were formed. Compound (1) (7-hydroxy-4-methyl Coumarin) was converted into 4-methylquinolin-2(H) derivative (2) by reaction with acetamide, and then reaction of (2) with thiosemicarbazide in ethanol leads to the synthesize of hydrazincarbothioamide derivative (3).The reaction of (3) with ethylchloroacetate in presence of sodium acetate leads to closure ring to get [(1-(5-oxo-2-thioxoimidazolidin-1-ylimino) ethyl)]quinolin-2(1H)-one (4). Mannich bases were prepared through the reaction of (4) with primary amines to form compounds (5-6). New coumarin derivatives were characterized by their physical properties and various spectral analysis like: FTIR, 1HNMR spectra and GC-Mass spectrum for some of them.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2769": coumarin, thioxoimidazolidin, methylquinolin" |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin مجلة بغداد للعلوم ": coumarin, thioxoimidazolidin, methylquinolin" |
| title | Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin |
| title_full | Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin |
| title_fullStr | Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin |
| title_full_unstemmed | Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin |
| title_short | Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin |
| title_sort | synthesis and characterization of new mannich bases derived from 7 hydroxy 4 methyl coumarin |
| topic | ": coumarin, thioxoimidazolidin, methylquinolin" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2769 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofnewmannichbasesderivedfrom7hydroxy4methylcoumarin |