Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case
Despite the low incidence of nasopharyngeal tumors, the treatment of patients with this disease remains an important and intricate issue. Its risk factors include smoking and alcoholism. About 60% of nasopharyngeal cancer cases are detected at Stages III–IV due to the fact that the early disease sta...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-11-01
|
| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849401729302396928 |
|---|---|
| author | Z. A. Radzhabova E. V. Tkachenko I. A. Morozov D. A. Rakitina R. A. Nazhmudinov |
| author_facet | Z. A. Radzhabova E. V. Tkachenko I. A. Morozov D. A. Rakitina R. A. Nazhmudinov |
| author_sort | Z. A. Radzhabova |
| collection | DOAJ |
| description | Despite the low incidence of nasopharyngeal tumors, the treatment of patients with this disease remains an important and intricate issue. Its risk factors include smoking and alcoholism. About 60% of nasopharyngeal cancer cases are detected at Stages III–IV due to the fact that the early disease stages are latent. The diagnosis of the disease is difficult because of the specific features of the anatomy of the nasopharynx and physicians’ errors. Chemotherapy can relieve pain in patients and considerably improve their quality of life. Chemoradiation therapy is a main treatment option for locally advanced forms. The now range of choice of chemopreparations is narrow so data on successful chemotherapy are particularly valuable. The effectiveness of therapy depends on a patient’s general health state and comorbid condition. The frequency of complications after chemotherapy is high. Some patients are at risk for febrile neutropenia. The risk factors include over 65 years of age; hyponutrition; previous aggressive chemotherapy; the presence of open wounds; chronic obstructive pulmonary disease; and low hemoglobin levels. It is necessary to thoroughly control clinical blood tests, to alleviate the manifestations of mucositis, to evaluate the effect of performed therapy after each even cycle, and to perform computed tomography of the chest and abdomen and spiral computed tomography of the head and neck. In the absence of contraindications to radiotherapy, this technique should be considered during treatment planning. In patients with nasopharyngeal cancer, the efficiency of performed chemoradiation treatment is higher than that of chemotherapy only. |
| format | Article |
| id | doaj-art-5a4842bb7bcd407aba9bbe0fb773e02e |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2015-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-5a4842bb7bcd407aba9bbe0fb773e02e2025-08-20T03:37:43ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-11-0153555810.17650/2222-1468-2015-5-3-55-58165Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical caseZ. A. Radzhabova0E. V. Tkachenko1I. A. Morozov2D. A. Rakitina3R. A. Nazhmudinov4N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, RussiaN.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, RussiaTerritorial Clinical Cancer Center; 164 Voronezhskoe Shosse, Khabarovsk, 680042, RussiaN.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, RussiaN.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, RussiaDespite the low incidence of nasopharyngeal tumors, the treatment of patients with this disease remains an important and intricate issue. Its risk factors include smoking and alcoholism. About 60% of nasopharyngeal cancer cases are detected at Stages III–IV due to the fact that the early disease stages are latent. The diagnosis of the disease is difficult because of the specific features of the anatomy of the nasopharynx and physicians’ errors. Chemotherapy can relieve pain in patients and considerably improve their quality of life. Chemoradiation therapy is a main treatment option for locally advanced forms. The now range of choice of chemopreparations is narrow so data on successful chemotherapy are particularly valuable. The effectiveness of therapy depends on a patient’s general health state and comorbid condition. The frequency of complications after chemotherapy is high. Some patients are at risk for febrile neutropenia. The risk factors include over 65 years of age; hyponutrition; previous aggressive chemotherapy; the presence of open wounds; chronic obstructive pulmonary disease; and low hemoglobin levels. It is necessary to thoroughly control clinical blood tests, to alleviate the manifestations of mucositis, to evaluate the effect of performed therapy after each even cycle, and to perform computed tomography of the chest and abdomen and spiral computed tomography of the head and neck. In the absence of contraindications to radiotherapy, this technique should be considered during treatment planning. In patients with nasopharyngeal cancer, the efficiency of performed chemoradiation treatment is higher than that of chemotherapy only.https://ogsh.abvpress.ru/jour/article/view/173nasopharyngeal cancerrecurrencenasopharyngeal squamous cell carcinomachemotherapycisplatindocetaxelblood indicatorschemotherapy complicationschest computed tomographyabdominal computed tomographyosteoscintigraphyspiral computed tomography of the head and neck |
| spellingShingle | Z. A. Radzhabova E. V. Tkachenko I. A. Morozov D. A. Rakitina R. A. Nazhmudinov Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case Опухоли головы и шеи nasopharyngeal cancer recurrence nasopharyngeal squamous cell carcinoma chemotherapy cisplatin docetaxel blood indicators chemotherapy complications chest computed tomography abdominal computed tomography osteoscintigraphy spiral computed tomography of the head and neck |
| title | Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case |
| title_full | Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case |
| title_fullStr | Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case |
| title_full_unstemmed | Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case |
| title_short | Successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases: a clinical case |
| title_sort | successful treatment for disseminated nasopharyngeal cancer with bone marrow metastases a clinical case |
| topic | nasopharyngeal cancer recurrence nasopharyngeal squamous cell carcinoma chemotherapy cisplatin docetaxel blood indicators chemotherapy complications chest computed tomography abdominal computed tomography osteoscintigraphy spiral computed tomography of the head and neck |
| url | https://ogsh.abvpress.ru/jour/article/view/173 |
| work_keys_str_mv | AT zaradzhabova successfultreatmentfordisseminatednasopharyngealcancerwithbonemarrowmetastasesaclinicalcase AT evtkachenko successfultreatmentfordisseminatednasopharyngealcancerwithbonemarrowmetastasesaclinicalcase AT iamorozov successfultreatmentfordisseminatednasopharyngealcancerwithbonemarrowmetastasesaclinicalcase AT darakitina successfultreatmentfordisseminatednasopharyngealcancerwithbonemarrowmetastasesaclinicalcase AT ranazhmudinov successfultreatmentfordisseminatednasopharyngealcancerwithbonemarrowmetastasesaclinicalcase |