Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction
A multi-marker approach for assessing the prognosis of patients with ST-segment elevation myocardial infarction (STEMI) is a promising strategy.Aim. To assess the potential prognostic power of soluble growth stimulation gene-2 (sST2), pentraxin 3 (PTX3), and N-terminal pro-brain natriuretic peptide...
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«FIRMA «SILICEA» LLC
2020-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3948 |
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| author | D. F. Gareeva A. F. Khamitova I. A. Lakman R. P. Ronzhin R. Kh. Zulkarneev M. R. Plotnikova E. L. Tulbaev L. J. Motloch N. Sh. Zagidullin |
| author_facet | D. F. Gareeva A. F. Khamitova I. A. Lakman R. P. Ronzhin R. Kh. Zulkarneev M. R. Plotnikova E. L. Tulbaev L. J. Motloch N. Sh. Zagidullin |
| author_sort | D. F. Gareeva |
| collection | DOAJ |
| description | A multi-marker approach for assessing the prognosis of patients with ST-segment elevation myocardial infarction (STEMI) is a promising strategy.Aim. To assess the potential prognostic power of soluble growth stimulation gene-2 (sST2), pentraxin 3 (PTX3), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in stratification of the risk of major cardiovascular events (CVE) during 2-year follow-up after STEMI.Material and methods. In 154 patients with STEMI, serum concentrations of NT-proBNP, sST2, and PTx-3 were determined upon admission to hospital. During the two-year follow-up period (734,2±61,2 days), correlation of biomarker concentrations with the risk of a composite endpoint (myocardial infarction + stroke + hospitalization due to cardiovascular disease + cardiovascular death) was analyzed.Results. In the 2-year follow-up, CVE were observed in 81 (55,1%) patients (CV death (n=33; 22,1%), recurrent MI (n=28; 18,.8%), stroke (n=8; 5,4%), hospitalization due to cardiovascular disease other than MI, stroke or cardiovascular death (n=12; 8,2%)). NT-proBNP (HR, 1,19; 95% CI, 1,018-1,32, p<0,001) and sST2 (HR, 1,000013; 95% CI, 1,00-1,001, p=0,007) correlated with CVE in contrast to PTX-3 (HR, 1,178; 95% CI, 0,798-1,73, p=0,434). The most accurate prediction of CVE was shown in the model with three biomarkers (AIC=831, BIC=843, LR=12,45, p=0,033). Conclusion. After STEMI, NT-proBNP and sST2, but not PTX-3, predicted CVE, while 3-marker analysis showed higher accuracy compared to single- and doublemarker. |
| format | Article |
| id | doaj-art-5a47b0e7d31b4e299e3de3a2f32b6428 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-5a47b0e7d31b4e299e3de3a2f32b64282025-08-20T03:20:55Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-12-01251210.15829/1560-4071-2020-39483007Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarctionD. F. Gareeva0A. F. Khamitova1I. A. Lakman2R. P. Ronzhin3R. Kh. Zulkarneev4M. R. Plotnikova5E. L. Tulbaev6L. J. Motloch7N. Sh. Zagidullin8Bashkir State Medical UniversityBashkir State Medical UniversityUfa State Aviation Technical UniversityUfa State Aviation Technical UniversityBashkir State Medical University; Ufa State Aviation Technical UniversityBashkir State Medical UniversityBashkir State Medical UniversityUniversity Clinic of Internal Medicine II, Paracelsus Medical UniversityBashkir State Medical University; Ufa State Aviation Technical UniversityA multi-marker approach for assessing the prognosis of patients with ST-segment elevation myocardial infarction (STEMI) is a promising strategy.Aim. To assess the potential prognostic power of soluble growth stimulation gene-2 (sST2), pentraxin 3 (PTX3), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in stratification of the risk of major cardiovascular events (CVE) during 2-year follow-up after STEMI.Material and methods. In 154 patients with STEMI, serum concentrations of NT-proBNP, sST2, and PTx-3 were determined upon admission to hospital. During the two-year follow-up period (734,2±61,2 days), correlation of biomarker concentrations with the risk of a composite endpoint (myocardial infarction + stroke + hospitalization due to cardiovascular disease + cardiovascular death) was analyzed.Results. In the 2-year follow-up, CVE were observed in 81 (55,1%) patients (CV death (n=33; 22,1%), recurrent MI (n=28; 18,.8%), stroke (n=8; 5,4%), hospitalization due to cardiovascular disease other than MI, stroke or cardiovascular death (n=12; 8,2%)). NT-proBNP (HR, 1,19; 95% CI, 1,018-1,32, p<0,001) and sST2 (HR, 1,000013; 95% CI, 1,00-1,001, p=0,007) correlated with CVE in contrast to PTX-3 (HR, 1,178; 95% CI, 0,798-1,73, p=0,434). The most accurate prediction of CVE was shown in the model with three biomarkers (AIC=831, BIC=843, LR=12,45, p=0,033). Conclusion. After STEMI, NT-proBNP and sST2, but not PTX-3, predicted CVE, while 3-marker analysis showed higher accuracy compared to single- and doublemarker.https://russjcardiol.elpub.ru/jour/article/view/3948stemicardiovascular eventscardiovascular deathrisk stratificationsst2nt-probnppentraxin-3 |
| spellingShingle | D. F. Gareeva A. F. Khamitova I. A. Lakman R. P. Ronzhin R. Kh. Zulkarneev M. R. Plotnikova E. L. Tulbaev L. J. Motloch N. Sh. Zagidullin Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction Российский кардиологический журнал stemi cardiovascular events cardiovascular death risk stratification sst2 nt-probnp pentraxin-3 |
| title | Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction |
| title_full | Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction |
| title_fullStr | Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction |
| title_full_unstemmed | Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction |
| title_short | Prognostic significance of a combination of novel biomarkers in the long-term stratification of adverse outcomes in patients with ST-segment elevation myocardial infarction |
| title_sort | prognostic significance of a combination of novel biomarkers in the long term stratification of adverse outcomes in patients with st segment elevation myocardial infarction |
| topic | stemi cardiovascular events cardiovascular death risk stratification sst2 nt-probnp pentraxin-3 |
| url | https://russjcardiol.elpub.ru/jour/article/view/3948 |
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