Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy

Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy

Abstract Immunotherapy is a breakthrough in the treatment of triple-negative breast cancer (TNBC), although it is only effective in a portion of patients. Our clinical studies find that pathological elevated level of reactive oxygen species (ROS) and lipid homeostasis imbalance are closely associate...

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Main Authors: Mengchi Sun, Yuxia Wu, Zhichao Chen, Boyan Zhang, Xiaoyang Liu, Peipei Ouyang, Ping Chen, Lujun Chen, Zhonggui He, Tao Han, Heran Li, Jin Sun, Shuang Cai, Qiuhua Luo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62543-x
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