Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug
Aim of review. To discuss results of application of the Russian drug dalargin in the treatment of gastroenterological diseases. Summary. Dalargin is the first synthetic opioid peptide agent created on the basis of endogenous leucineenkephaline. Pharmacological effects of dalargin are caused by opioi...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2016-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/65 |
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| _version_ | 1823860129320140800 |
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| author | S. A. Bulgakov |
| author_facet | S. A. Bulgakov |
| author_sort | S. A. Bulgakov |
| collection | DOAJ |
| description | Aim of review. To discuss results of application of the Russian drug dalargin in the treatment of gastroenterological diseases. Summary. Dalargin is the first synthetic opioid peptide agent created on the basis of endogenous leucineenkephaline. Pharmacological effects of dalargin are caused by opioid receptors. The pilot studies showed protective properties for ulceration and antisecretory effect. In therapeutic practice it is applied for treatment of peptic ulcer of the stomach and duodenum, acute and chronic pancreatitis and pancreatic necrosis. Article presents results of use of hexapeptide, algorithm and guideline on its application are analyzed, possible mechanisms of action are discussed. The therapeutic effect of dalargin at various gastro-intestinal diseases is determined by its bioregulator properties maintaining body homeostasis up to standard. Conclusion. Dalargin has demonstrated high therapeutic efficacy and safety for almost 30 years of application in practical gastroenterology and significantly expanded facilities of gastroenterologists in treatment of digestive diseases. |
| format | Article |
| id | doaj-art-5a4672f26ef74967a54645528f495316 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2016-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5a4672f26ef74967a54645528f4953162025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732016-08-0126310311210.22416/1382-4376-2016-26-3-103-11265Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drugS. A. Bulgakov0State educational government-financed institution of higher professional education «Pirogov Russian national research medical university»Aim of review. To discuss results of application of the Russian drug dalargin in the treatment of gastroenterological diseases. Summary. Dalargin is the first synthetic opioid peptide agent created on the basis of endogenous leucineenkephaline. Pharmacological effects of dalargin are caused by opioid receptors. The pilot studies showed protective properties for ulceration and antisecretory effect. In therapeutic practice it is applied for treatment of peptic ulcer of the stomach and duodenum, acute and chronic pancreatitis and pancreatic necrosis. Article presents results of use of hexapeptide, algorithm and guideline on its application are analyzed, possible mechanisms of action are discussed. The therapeutic effect of dalargin at various gastro-intestinal diseases is determined by its bioregulator properties maintaining body homeostasis up to standard. Conclusion. Dalargin has demonstrated high therapeutic efficacy and safety for almost 30 years of application in practical gastroenterology and significantly expanded facilities of gastroenterologists in treatment of digestive diseases.https://www.gastro-j.ru/jour/article/view/65даларгингексапептидтерапияязвенная болезньострый и хронический панкреатитпанкреонекроз |
| spellingShingle | S. A. Bulgakov Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug Российский журнал гастроэнтерологии, гепатологии, колопроктологии даларгин гексапептид терапия язвенная болезнь острый и хронический панкреатит панкреонекроз |
| title | Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug |
| title_full | Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug |
| title_fullStr | Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug |
| title_full_unstemmed | Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug |
| title_short | Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug |
| title_sort | hexapeptide dalargin in clinical gastroenterology 30 years of clinical application of the drug |
| topic | даларгин гексапептид терапия язвенная болезнь острый и хронический панкреатит панкреонекроз |
| url | https://www.gastro-j.ru/jour/article/view/65 |
| work_keys_str_mv | AT sabulgakov hexapeptidedalargininclinicalgastroenterology30yearsofclinicalapplicationofthedrug |