Application of immunohistochemical markers in mycosis fungoides
Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. Immunohistochemical (IHC) staining is a commonly used diagnostic...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-01-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.010 |
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| _version_ | 1825199570599018496 |
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| author | SHAO Kaixin LIU Xiangjun TANG Zhenzhen |
| author_facet | SHAO Kaixin LIU Xiangjun TANG Zhenzhen |
| author_sort | SHAO Kaixin |
| collection | DOAJ |
| description | Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. Immunohistochemical (IHC) staining is a commonly used diagnostic method in clinical practice. Common markers such as CD4, CD8, CD20, and CD30 have different expression patterns in mycosis fungoides. In addition, these markers can also be used to evaluate the degree of disease progression and prognosis. In-depth research on immunohistochemical markers helps better understand the pathogenesis of MF and provides a more accurate basis for clinical treatment, such as guiding the selection of treatment regimens and evaluating treatment effects, in addition to its indispensable role in the clinical management of MF. This article reviews the role of IHC markers in the diagnosis and prognosis of MF and explores the application value of different molecular marker patterns. |
| format | Article |
| id | doaj-art-5a40107676eb47599323a839eb784f02 |
| institution | Kabale University |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-5a40107676eb47599323a839eb784f022025-02-08T03:48:35Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-01-01321566310.3969/j.issn.1674-8468.2025.01.010Application of immunohistochemical markers in mycosis fungoidesSHAO Kaixin0LIU Xiangjun1TANG Zhenzhen2Leling People′s Hospital, Leling 253600, ChinaQilu Hospital of Shandong University, Jinan 250000, ChinaLanling People′s Hospital, Lanling 277700, ChinaMycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphomas. Most cases of MF progress slowly with a good prognosis. However, some early-stage patients may still experience disease progression with a poor prognosis. Immunohistochemical (IHC) staining is a commonly used diagnostic method in clinical practice. Common markers such as CD4, CD8, CD20, and CD30 have different expression patterns in mycosis fungoides. In addition, these markers can also be used to evaluate the degree of disease progression and prognosis. In-depth research on immunohistochemical markers helps better understand the pathogenesis of MF and provides a more accurate basis for clinical treatment, such as guiding the selection of treatment regimens and evaluating treatment effects, in addition to its indispensable role in the clinical management of MF. This article reviews the role of IHC markers in the diagnosis and prognosis of MF and explores the application value of different molecular marker patterns.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.010cutaneous t cell lymphomamycosis fungoidesimmunohistochemical stainingprognosis |
| spellingShingle | SHAO Kaixin LIU Xiangjun TANG Zhenzhen Application of immunohistochemical markers in mycosis fungoides Pifu-xingbing zhenliaoxue zazhi cutaneous t cell lymphoma mycosis fungoides immunohistochemical staining prognosis |
| title | Application of immunohistochemical markers in mycosis fungoides |
| title_full | Application of immunohistochemical markers in mycosis fungoides |
| title_fullStr | Application of immunohistochemical markers in mycosis fungoides |
| title_full_unstemmed | Application of immunohistochemical markers in mycosis fungoides |
| title_short | Application of immunohistochemical markers in mycosis fungoides |
| title_sort | application of immunohistochemical markers in mycosis fungoides |
| topic | cutaneous t cell lymphoma mycosis fungoides immunohistochemical staining prognosis |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.010 |
| work_keys_str_mv | AT shaokaixin applicationofimmunohistochemicalmarkersinmycosisfungoides AT liuxiangjun applicationofimmunohistochemicalmarkersinmycosisfungoides AT tangzhenzhen applicationofimmunohistochemicalmarkersinmycosisfungoides |