Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy
Veterinary specialists have lately observed comorbidity of heart and kidney diseases known as cardiorenal syndrome. Cardiorenal syndrome is typically defined as dysfunction of a primarily intact kidney under the influence of a complex of pathogenetic damaging factors that arise against the backgroun...
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| Format: | Article |
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Da Vinci Media
2024-12-01
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| Series: | Ветеринария сегодня |
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| Online Access: | https://veterinary.arriah.ru/jour/article/view/874 |
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| author | Yu. A. Vatnikov E. D. Sotnikova V. I. Kuznetsov A. A. Razumova I. V. Shchurov O. A. Petrukhina A. A. Rudenko |
| author_facet | Yu. A. Vatnikov E. D. Sotnikova V. I. Kuznetsov A. A. Razumova I. V. Shchurov O. A. Petrukhina A. A. Rudenko |
| author_sort | Yu. A. Vatnikov |
| collection | DOAJ |
| description | Veterinary specialists have lately observed comorbidity of heart and kidney diseases known as cardiorenal syndrome. Cardiorenal syndrome is typically defined as dysfunction of a primarily intact kidney under the influence of a complex of pathogenetic damaging factors that arise against the background of an underlying cardiac disease. The purpose of the work is to study the biochemical profile of blood serum in cats with cardiorenal syndrome arising against the background of hypertrophic cardiomyopathy. The studies were carried out on 24 physiologically healthy (control) cats, 24 diseased cats with uncomplicated forms of pathology (first group) and 25 cats with hypertrophic cardiomyopathy complicated by cardiorenal syndrome (second group). It was shown that cardiorenal syndrome may occur as a complication of hypertrophic cardiomyopathy in animals. Biochemical tests in animals with feline cardiorenal syndrome verified cytolysis of cardiomyocytes (increased serum activity of lactate dehydrogenase by 2.69 times, creatine phosphokinase by 2.02 times, increased serum concentration of cardiac troponin by 5.20 times as compared to healthy animals), azotemia (increased concentration in serum creatinine by 2.72 times, urea by 2.94 times, symmetric dimethylarginine by 2.60 times and cystatin C by 1.90 times as compared to healthy animals), enhanced ketogenesis, systemic inflammatory process (increased serum concentration of C-reactive protein by 1.55 times as compared to healthy animals), hypercholesterolemia, oxidative stress (decrease in serum activity of superoxide dismutase by 1.63 times, catalase by 4.67 times and glutathione peroxidase by 1.71 times, increase in the concentration of malondialdehyde by 1.79 times, ceruloplasmin by 2.50 times and diene conjugates by 1.85 times as compared to healthy animals), electrolyte imbalance in the form of hyperkalemia, hyponatremia, hyperphosphatemia and hypomagnesemia. Biochemical indicators such as serum concentrations of creatinine, troponin I, cystatin C, symmetric dimethylarginine and C-reactive protein can be considered reliable diagnostic markers for the presence of cardiorenal syndrome. |
| format | Article |
| id | doaj-art-5a3d720b41b84450a1a0e2de67b5d0b4 |
| institution | Kabale University |
| issn | 2304-196X 2658-6959 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Da Vinci Media |
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| series | Ветеринария сегодня |
| spelling | doaj-art-5a3d720b41b84450a1a0e2de67b5d0b42025-02-06T09:52:11ZengDa Vinci MediaВетеринария сегодня2304-196X2658-69592024-12-0113438739510.29326/2304-196X-2024-13-4-387-395699Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathyYu. A. Vatnikov0E. D. Sotnikova1V. I. Kuznetsov2A. A. Razumova3I. V. Shchurov4O. A. Petrukhina5A. A. Rudenko6Peoples’Friendship University of Russia named after Patrice LumumbaPeoples’Friendship University of Russia named after Patrice LumumbaPeoples’Friendship University of Russia named after Patrice LumumbaFederal Centre for Animal HealthPeoples’Friendship University of Russia named after Patrice LumumbaPeoples’Friendship University of Russia named after Patrice LumumbaRussian Biotechnological UniversityVeterinary specialists have lately observed comorbidity of heart and kidney diseases known as cardiorenal syndrome. Cardiorenal syndrome is typically defined as dysfunction of a primarily intact kidney under the influence of a complex of pathogenetic damaging factors that arise against the background of an underlying cardiac disease. The purpose of the work is to study the biochemical profile of blood serum in cats with cardiorenal syndrome arising against the background of hypertrophic cardiomyopathy. The studies were carried out on 24 physiologically healthy (control) cats, 24 diseased cats with uncomplicated forms of pathology (first group) and 25 cats with hypertrophic cardiomyopathy complicated by cardiorenal syndrome (second group). It was shown that cardiorenal syndrome may occur as a complication of hypertrophic cardiomyopathy in animals. Biochemical tests in animals with feline cardiorenal syndrome verified cytolysis of cardiomyocytes (increased serum activity of lactate dehydrogenase by 2.69 times, creatine phosphokinase by 2.02 times, increased serum concentration of cardiac troponin by 5.20 times as compared to healthy animals), azotemia (increased concentration in serum creatinine by 2.72 times, urea by 2.94 times, symmetric dimethylarginine by 2.60 times and cystatin C by 1.90 times as compared to healthy animals), enhanced ketogenesis, systemic inflammatory process (increased serum concentration of C-reactive protein by 1.55 times as compared to healthy animals), hypercholesterolemia, oxidative stress (decrease in serum activity of superoxide dismutase by 1.63 times, catalase by 4.67 times and glutathione peroxidase by 1.71 times, increase in the concentration of malondialdehyde by 1.79 times, ceruloplasmin by 2.50 times and diene conjugates by 1.85 times as compared to healthy animals), electrolyte imbalance in the form of hyperkalemia, hyponatremia, hyperphosphatemia and hypomagnesemia. Biochemical indicators such as serum concentrations of creatinine, troponin I, cystatin C, symmetric dimethylarginine and C-reactive protein can be considered reliable diagnostic markers for the presence of cardiorenal syndrome.https://veterinary.arriah.ru/jour/article/view/874cardiorenal syndromepathogenesisbiochemistrypathochemistrycatshypertrophic cardiomyopathy |
| spellingShingle | Yu. A. Vatnikov E. D. Sotnikova V. I. Kuznetsov A. A. Razumova I. V. Shchurov O. A. Petrukhina A. A. Rudenko Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy Ветеринария сегодня cardiorenal syndrome pathogenesis biochemistry pathochemistry cats hypertrophic cardiomyopathy |
| title | Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| title_full | Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| title_fullStr | Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| title_full_unstemmed | Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| title_short | Serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| title_sort | serum biochemical profile in case of cardiorenal syndrome in cats with hypertrophic cardiomyopathy |
| topic | cardiorenal syndrome pathogenesis biochemistry pathochemistry cats hypertrophic cardiomyopathy |
| url | https://veterinary.arriah.ru/jour/article/view/874 |
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