The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells
Although type 1 diabetes is thought to be an organ-specific autoimmune disease, mediated by effective CD4+ and CD8+ T cells, it has recently become clear that B cells participate in the initiation and progress of this disease. Indeed, B cell deletion can prevent or reverse autoimmune diabetes in non...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6581213 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850224936073822208 |
|---|---|
| author | Yangfan Xiao Chao Deng Zhiguang Zhou |
| author_facet | Yangfan Xiao Chao Deng Zhiguang Zhou |
| author_sort | Yangfan Xiao |
| collection | DOAJ |
| description | Although type 1 diabetes is thought to be an organ-specific autoimmune disease, mediated by effective CD4+ and CD8+ T cells, it has recently become clear that B cells participate in the initiation and progress of this disease. Indeed, B cell deletion can prevent or reverse autoimmune diabetes in nonobese diabetic mice and even result in partially remaining β cell function in patients with new-onset type 1 diabetes. This review summarizes the dual role of B cells in this process not only of pathogenic effect but also of immunoregulatory function in type 1 diabetes. We focus on the impact that B cells have on regulating the activation, proliferation, and cytokine production of self-reactive T cells along with regulatory T cells, with the aim of providing a better understanding of the interactions between T and B cells in immunopathogenesis and improving the efficacy of interventions for clinical practice. |
| format | Article |
| id | doaj-art-5a3d71dfdab34bcd8cb6ba363a5b9c63 |
| institution | OA Journals |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5a3d71dfdab34bcd8cb6ba363a5b9c632025-08-20T02:05:29ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/6581213The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T CellsYangfan Xiao0Chao Deng1Zhiguang Zhou2Clinical Nursing Teaching and Research SectionNational Clinical Research Center for Metabolic DiseasesNational Clinical Research Center for Metabolic DiseasesAlthough type 1 diabetes is thought to be an organ-specific autoimmune disease, mediated by effective CD4+ and CD8+ T cells, it has recently become clear that B cells participate in the initiation and progress of this disease. Indeed, B cell deletion can prevent or reverse autoimmune diabetes in nonobese diabetic mice and even result in partially remaining β cell function in patients with new-onset type 1 diabetes. This review summarizes the dual role of B cells in this process not only of pathogenic effect but also of immunoregulatory function in type 1 diabetes. We focus on the impact that B cells have on regulating the activation, proliferation, and cytokine production of self-reactive T cells along with regulatory T cells, with the aim of providing a better understanding of the interactions between T and B cells in immunopathogenesis and improving the efficacy of interventions for clinical practice.http://dx.doi.org/10.1155/2021/6581213 |
| spellingShingle | Yangfan Xiao Chao Deng Zhiguang Zhou The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells Journal of Diabetes Research |
| title | The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells |
| title_full | The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells |
| title_fullStr | The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells |
| title_full_unstemmed | The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells |
| title_short | The Multiple Roles of B Lymphocytes in the Onset and Treatment of Type 1 Diabetes: Interactions between B Lymphocytes and T Cells |
| title_sort | multiple roles of b lymphocytes in the onset and treatment of type 1 diabetes interactions between b lymphocytes and t cells |
| url | http://dx.doi.org/10.1155/2021/6581213 |
| work_keys_str_mv | AT yangfanxiao themultiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells AT chaodeng themultiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells AT zhiguangzhou themultiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells AT yangfanxiao multiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells AT chaodeng multiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells AT zhiguangzhou multiplerolesofblymphocytesintheonsetandtreatmentoftype1diabetesinteractionsbetweenblymphocytesandtcells |