Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022
Aim. This study aimed to assess the influence of female sex and type 2 diabetes mellitus (T2DM) on in-hospital mortality among patients diagnosed with acute coronary syndrome (ACS) in the emergency department during the period 20152022, while also exploring the association of relevant laboratory fac...
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| Language: | Russian |
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«FIRMA «SILICEA» LLC
2024-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5740 |
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| author | Alejandra Guzmán Quiroga Alexander Bustamante Cabrejo José Caballero-Alvarado Carlos Zavaleta-Corvera Othoniel Burgos Chávez |
| author_facet | Alejandra Guzmán Quiroga Alexander Bustamante Cabrejo José Caballero-Alvarado Carlos Zavaleta-Corvera Othoniel Burgos Chávez |
| author_sort | Alejandra Guzmán Quiroga |
| collection | DOAJ |
| description | Aim. This study aimed to assess the influence of female sex and type 2 diabetes mellitus (T2DM) on in-hospital mortality among patients diagnosed with acute coronary syndrome (ACS) in the emergency department during the period 20152022, while also exploring the association of relevant laboratory factors.Material and methods. An observational, analytical, retrospective cohort study was conducted, focusing on patients diagnosed with acute coronary syndrome who had high-density lipoprotein (HDL) values measured. The study included a total of 196 patients, divided into diabetes and non-diabetes groups, totaling 98 patients in each.Results. Among the 196 patients with acute coronary syndrome, 181 survived, and 15 succumbed until hospital discharge. Statistically significant associations were identified between female sex (relative risk (RR): 3.52, 95% confidential interval (CI): 1.25-9.92, p=0.017) and T2DM (RR: 4.05, 95% CI: 1.51-10.85, p=0.005) withan increased risk of mortality in acute coronary syndrome patients. Notably, high HDL values did not exhibit a statistically significant association (RR: 0.88, 95% CI: 0.33-2.33, p=0.789). Subsequent multivariate analysis reaffirmed the significant association, indicating a 20% increased risk of death in patients with T2DM and acute coronary syndrome (RR: 1.2, 95% CI: 0.15-2.25, p=0.025).Conclusion. The study concludes that while elevated HDL levels are not associated with increased in-hospital mortality in acute coronary syndrome patients, T2DM emerges as a noteworthy factor influencing this outcome. |
| format | Article |
| id | doaj-art-5a3befbba029438cb57f8e319dfe1e96 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-5a3befbba029438cb57f8e319dfe1e962025-08-20T03:00:50Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-06-0129610.15829/1560-4071-2024-57404052Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022Alejandra Guzmán Quiroga0Alexander Bustamante Cabrejo1José Caballero-Alvarado2Carlos Zavaleta-Corvera3Othoniel Burgos Chávez4School of Medicine, Antenor Orrego Private UniversitySchool of Medicine, Antenor Orrego Private University; High Complexity Hospital, Virgen de la PuertaSchool of Medicine, Antenor Orrego Private UniversitySchool of Medicine, Antenor Orrego Private UniversitySchool of Medicine, Antenor Orrego Private University; High Complexity Hospital, Virgen de la PuertaAim. This study aimed to assess the influence of female sex and type 2 diabetes mellitus (T2DM) on in-hospital mortality among patients diagnosed with acute coronary syndrome (ACS) in the emergency department during the period 20152022, while also exploring the association of relevant laboratory factors.Material and methods. An observational, analytical, retrospective cohort study was conducted, focusing on patients diagnosed with acute coronary syndrome who had high-density lipoprotein (HDL) values measured. The study included a total of 196 patients, divided into diabetes and non-diabetes groups, totaling 98 patients in each.Results. Among the 196 patients with acute coronary syndrome, 181 survived, and 15 succumbed until hospital discharge. Statistically significant associations were identified between female sex (relative risk (RR): 3.52, 95% confidential interval (CI): 1.25-9.92, p=0.017) and T2DM (RR: 4.05, 95% CI: 1.51-10.85, p=0.005) withan increased risk of mortality in acute coronary syndrome patients. Notably, high HDL values did not exhibit a statistically significant association (RR: 0.88, 95% CI: 0.33-2.33, p=0.789). Subsequent multivariate analysis reaffirmed the significant association, indicating a 20% increased risk of death in patients with T2DM and acute coronary syndrome (RR: 1.2, 95% CI: 0.15-2.25, p=0.025).Conclusion. The study concludes that while elevated HDL levels are not associated with increased in-hospital mortality in acute coronary syndrome patients, T2DM emerges as a noteworthy factor influencing this outcome.https://russjcardiol.elpub.ru/jour/article/view/5740high-density lipoprotein cholesterolacute coronary syndromeinhospital mortalityrisk factorsobservational study |
| spellingShingle | Alejandra Guzmán Quiroga Alexander Bustamante Cabrejo José Caballero-Alvarado Carlos Zavaleta-Corvera Othoniel Burgos Chávez Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 Российский кардиологический журнал high-density lipoprotein cholesterol acute coronary syndrome inhospital mortality risk factors observational study |
| title | Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 |
| title_full | Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 |
| title_fullStr | Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 |
| title_full_unstemmed | Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 |
| title_short | Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022 |
| title_sort | impact of female sex and type 2 diabetes mellitus on in hospital mortality among patients with acute coronary syndrome a retrospective cohort study between 2015 2022 |
| topic | high-density lipoprotein cholesterol acute coronary syndrome inhospital mortality risk factors observational study |
| url | https://russjcardiol.elpub.ru/jour/article/view/5740 |
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