Is neoadjuvant immunotherapy feasible for patients with dMMR/MSI−H locally advanced colorectal cancer? a retrospective study

Is neoadjuvant immunotherapy feasible for patients with dMMR/MSI−H locally advanced colorectal cancer? a retrospective study

BackgroundNeoadjuvant immunotherapy has demonstrated satisfactory efficacy for high microsatellite instability/mismatch repair deficiency (dMMR/MSI-H) in locally advanced colorectal cancer (LACRC). This study aims to evaluate the safety and short-term efficacy of neoadjuvant immunotherapy for patien...

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Bibliographic Details
Main Authors: Zhenkai Luo, Danjun Wang, Zhexue Wang, Hang Zhao, Renshen Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
locally advanced colorectal cancer
immunotherapy
neoadjuvant therapy
microsatellite instability
pathological complete response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1645412/full
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