Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA)
Introduction Community-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing f...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/10/1/e001806.full |
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| author | Aaron Scott Elizabeth Sapey David R Thickett Frances S Grudzinska Aduragbemi A Faniyi |
| author_facet | Aaron Scott Elizabeth Sapey David R Thickett Frances S Grudzinska Aduragbemi A Faniyi |
| author_sort | Aaron Scott |
| collection | DOAJ |
| description | Introduction Community-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing field which links immune cell function to metabolism. This study aims to explore neutrophil metabolism in community-acquired pneumonia.Methods and analysis Pneumonia Metabolism in Ageing study is a prospective observational study recruiting older adults hospitalised with community-acquired pneumonia to examine neutrophil function and metabolic status. Controls will be older adults with no acute illness. The primary endpoint is neutrophil chemotaxis.Ethics and dissemination The study has ethical approval from the Research Ethics Committee Wales, reference 19/WA/0299. This study involves participants who may lack the capacity to consent to research involvement, in this situation, personal or professional assent will be sought. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at local and international conferences. |
| format | Article |
| id | doaj-art-5a33216c7c434109918e7e82f56fbccd |
| institution | DOAJ |
| issn | 2052-4439 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-5a33216c7c434109918e7e82f56fbccd2025-08-20T02:57:59ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392023-07-0110110.1136/bmjresp-2023-001806Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA)Aaron Scott0Elizabeth Sapey1David R Thickett2Frances S Grudzinska3Aduragbemi A Faniyi4Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UKInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UKBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UKBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UKBirmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UKIntroduction Community-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing field which links immune cell function to metabolism. This study aims to explore neutrophil metabolism in community-acquired pneumonia.Methods and analysis Pneumonia Metabolism in Ageing study is a prospective observational study recruiting older adults hospitalised with community-acquired pneumonia to examine neutrophil function and metabolic status. Controls will be older adults with no acute illness. The primary endpoint is neutrophil chemotaxis.Ethics and dissemination The study has ethical approval from the Research Ethics Committee Wales, reference 19/WA/0299. This study involves participants who may lack the capacity to consent to research involvement, in this situation, personal or professional assent will be sought. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at local and international conferences.https://bmjopenrespres.bmj.com/content/10/1/e001806.full |
| spellingShingle | Aaron Scott Elizabeth Sapey David R Thickett Frances S Grudzinska Aduragbemi A Faniyi Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) BMJ Open Respiratory Research |
| title | Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) |
| title_full | Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) |
| title_fullStr | Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) |
| title_full_unstemmed | Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) |
| title_short | Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) |
| title_sort | observational cohort study protocol neutrophil function and energetics in adults with pneumonia and sepsis pneumonia metabolism in ageing puma |
| url | https://bmjopenrespres.bmj.com/content/10/1/e001806.full |
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